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Atomfair 2-(Trifluoromethyl)benzonitrile C8H4F3N

Description 2-(Trifluoromethyl)benzonitrile (CAS No. 447-60-9) is a high-purity aromatic nitrile compound with the molecular formula C8H4F3N. This versatile chemical features a trifluoromethyl group ortho to a nitrile functionality, making it a valuable intermediate in organic synthesis and pharmaceutical research. The compound is supplied as a clear to pale yellow liquid with a characteristic aromatic odor, and is rigorously tested to ensure ??98% purity (GC). Suitable for use in Grignard reactions, nucleophilic substitutions, and as a building block for agrochemicals and bioactive molecules. Packaged under inert gas in amber glass bottles to ensure stability and longevity.

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Description

Description

2-(Trifluoromethyl)benzonitrile (CAS No. 447-60-9) is a high-purity aromatic nitrile compound with the molecular formula C8H4F3N. This versatile chemical features a trifluoromethyl group ortho to a nitrile functionality, making it a valuable intermediate in organic synthesis and pharmaceutical research. The compound is supplied as a clear to pale yellow liquid with a characteristic aromatic odor, and is rigorously tested to ensure ??98% purity (GC). Suitable for use in Grignard reactions, nucleophilic substitutions, and as a building block for agrochemicals and bioactive molecules. Packaged under inert gas in amber glass bottles to ensure stability and longevity.

  • CAS No: 447-60-9
  • Molecular Formula: C8H4F3N
  • Molecular Weight: 171.12
  • Exact Mass: 171.02958362
  • Monoisotopic Mass: 171.02958362
  • IUPAC Name: 2-(trifluoromethyl)benzonitrile
  • SMILES: C1=CC=C(C(=C1)C#N)C(F)(F)F
  • Synonyms: 2-(Trifluoromethyl)benzonitrile, 447-60-9, 2-Cyanobenzotrifluoride, alpha,alpha,alpha-Trifluoro-o-tolunitrile, Benzonitrile, 2-(trifluoromethyl)-

Application

2-(Trifluoromethyl)benzonitrile serves as a key precursor in the synthesis of fluorinated pharmaceuticals and liquid crystal materials. Its electron-withdrawing trifluoromethyl group enhances reactivity in palladium-catalyzed cross-coupling reactions. Researchers utilize this compound to develop protease inhibitors and other bioactive molecules where fluorine substitution modulates metabolic stability. The nitrile group offers further derivatization potential via hydrolysis or reduction to primary amines.

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