Description

Description

2-(Trifluoromethoxy)benzoyl Chloride (CAS No. 116827-40-8) is a high-purity organic compound with the molecular formula C₈H₄ClF₃O₂. This specialized reagent features a benzoyl chloride core functionalized with a trifluoromethoxy group at the ortho position, making it a valuable building block for pharmaceutical and agrochemical synthesis. The compound is characterized by its reactivity as an acyl chloride, enabling efficient acylation reactions under mild conditions. Supplied as a clear to pale yellow liquid with >97% purity (GC), it is packaged under inert gas to ensure stability. Typical impurities include minor amounts of the corresponding carboxylic acid. Storage recommendations: maintain at 2-8??C in tightly sealed original containers. Hazard statements: H314 – Causes severe skin burns and eye damage.

Application

This benzoyl chloride derivative serves as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethoxy-substituted aromatic systems. It finds application in the preparation of liquid crystal materials due to its ability to modify molecular polarity. The compound is also employed in coupling reactions to create novel heterocyclic compounds for drug discovery programs. Researchers utilize it to introduce the 2-(trifluoromethoxy)benzoyl moiety into target molecules through nucleophilic substitution reactions.

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