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Atomfair 2′-O-Methyluridine C10H14N2O6

Description 2′-O-Methyluridine (CAS No. 2140-76-3) is a chemically modified nucleoside where the 2′-hydroxyl group of the ribose sugar is substituted with a methoxy group. This modification enhances its stability against enzymatic degradation, making it a valuable tool in nucleic acid research, oligonucleotide synthesis, and therapeutic applications. With the molecular formula C10H14N2O6and IUPAC name 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione , this compound is widely used in the study of RNA structure, function, and dynamics. It is particularly useful in the design of antisense oligonucleotides, siRNA, and other RNA-based therapeutics due to its ability to improve nuclease resistance and binding affinity. Our high-purity 2′-O-Methyluridine is rigorously…

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Description

Description

2′-O-Methyluridine (CAS No. 2140-76-3) is a chemically modified nucleoside where the 2′-hydroxyl group of the ribose sugar is substituted with a methoxy group. This modification enhances its stability against enzymatic degradation, making it a valuable tool in nucleic acid research, oligonucleotide synthesis, and therapeutic applications. With the molecular formula C10H14N2O6 and IUPAC name 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione, this compound is widely used in the study of RNA structure, function, and dynamics. It is particularly useful in the design of antisense oligonucleotides, siRNA, and other RNA-based therapeutics due to its ability to improve nuclease resistance and binding affinity. Our high-purity 2′-O-Methyluridine is rigorously tested for quality and consistency, ensuring reliable performance in your research applications.

  • CAS No: 2140-76-3
  • Molecular Formula: C10H14N2O6
  • Molecular Weight: 258.23
  • Exact Mass: 258.08518617
  • Monoisotopic Mass: 258.08518617
  • IUPAC Name: 1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione
  • SMILES: CO[C@@H]1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)CO)O
  • Synonyms: 2′-O-Methyluridine, 2140-76-3, Uridine, 2′-O-methyl-, O(2′)-Methyluridine, O2′-Methyluridine

Application

2′-O-Methyluridine is extensively used in RNA research for stabilizing oligonucleotides against degradation by nucleases. It plays a critical role in the synthesis of modified RNA strands for antisense and siRNA applications. Researchers also employ it to study RNA-protein interactions and to enhance the thermal stability of RNA duplexes. Its incorporation into oligonucleotides can improve pharmacokinetic properties for therapeutic use.

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