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Atomfair 2-Iodo-4-methylpyridine C6H6IN

Description 2-Iodo-4-methylpyridine (CAS No. 22282-60-6) is a high-purity halogenated pyridine derivative with the molecular formula C6H6IN . This organoiodine compound is a valuable intermediate in pharmaceutical and agrochemical synthesis, offering exceptional reactivity for cross-coupling reactions (e.g., Suzuki, Negishi). The methyl group at the 4-position enhances electron density, making it particularly useful for directed metalation and subsequent functionalization. Supplied as crystalline solid with ??98% purity (HPLC), it is rigorously tested for heavy metals (

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Description

Description

2-Iodo-4-methylpyridine (CAS No. 22282-60-6) is a high-purity halogenated pyridine derivative with the molecular formula C6H6IN. This organoiodine compound is a valuable intermediate in pharmaceutical and agrochemical synthesis, offering exceptional reactivity for cross-coupling reactions (e.g., Suzuki, Negishi). The methyl group at the 4-position enhances electron density, making it particularly useful for directed metalation and subsequent functionalization. Supplied as crystalline solid with ??98% purity (HPLC), it is rigorously tested for heavy metals (<10 ppm) and residual solvents. Optimal storage at 2-8??C under inert atmosphere ensures long-term stability. Available in research (1g, 5g) and bulk (25g, 100g) quantities with COA/MSDS documentation.

  • CAS No: 22282-60-6
  • Molecular Formula: C6H6IN
  • Molecular Weight: 219.02
  • Exact Mass: 218.95450
  • Monoisotopic Mass: 218.95450
  • IUPAC Name: 2-iodo-4-methylpyridine
  • SMILES: CC1=CC(=NC=C1)I
  • Synonyms: 2-Iodo-4-methylpyridine, 22282-60-6, DTXSID40494782, DTXCID40445592, 843-955-6

Application

2-Iodo-4-methylpyridine serves as a key building block in palladium-catalyzed cross-coupling reactions for drug discovery, particularly in synthesizing kinase inhibitors and antiviral compounds. The iodine moiety enables efficient Sonogashira couplings for alkyne-functionalized heterocycles. In material science, it acts as precursor for N-donor ligands in catalytic systems. The methyl group facilitates C-H activation in late-stage diversification of pharmaceutical intermediates.

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