Get FREE SHIPPING when you spend $99 or more | ATOMFAIR

Awaiting product image

Atomfair 2-Iodo-4-methylpyridine C6H6IN CAS 22282-60-6

2-Iodo-4-methylpyridine (CAS No. 22282-60-6) is a high-purity halogenated pyridine derivative with the molecular formula C6H6IN . This organoiodine compound is a valuable intermediate in pharmaceutical and agrochemical synthesis, offering exceptional reactivity for cross-coupling reactions (e.g., Suzuki, Negishi). The methyl group at the 4-position enhances electron density, making it particularly useful for directed metalation and subsequent functionalization. Supplied as crystalline solid with ≥98% purity (HPLC), it is rigorously tested for heavy metals (<10 ppm) and residual solvents. Optimal storage at 2-8°C under inert atmosphere ensures long-term stability. Available in research (1g, 5g) and bulk (25g, 100g) quantities with COA/MSDS documentation.

Category:

Description

2-Iodo-4-methylpyridine (CAS No. 22282-60-6) is a high-purity halogenated pyridine derivative with the molecular formula C6H6IN. This organoiodine compound is a valuable intermediate in pharmaceutical and agrochemical synthesis, offering exceptional reactivity for cross-coupling reactions (e.g., Suzuki, Negishi). The methyl group at the 4-position enhances electron density, making it particularly useful for directed metalation and subsequent functionalization. Supplied as crystalline solid with ≥98% purity (HPLC), it is rigorously tested for heavy metals (<10 ppm) and residual solvents. Optimal storage at 2-8°C under inert atmosphere ensures long-term stability. Available in research (1g, 5g) and bulk (25g, 100g) quantities with COA/MSDS documentation.

Properties

  • CAS Number: 22282-60-6
  • Complexity: 74.9
  • IUPAC Name: 2-iodo-4-methyl-pyridine
  • InChI: InChI=1S/C6H6IN/c1-5-2-3-8-6(7)4-5/h2-4H,1H3
  • InChI Key: DZFWKQYMUZMLSR-UHFFFAOYSA-N
  • Exact Mass: 218.95450
  • Molecular Formula: C6H6IN
  • Molecular Weight: 219.02
  • SMILES: CC1=CC(=NC=C1)I
  • Topological: 12.9
  • Monoisotopic Mass: 218.95450
  • Synonyms: 2-Iodo-4-methylpyridine, 22282-60-6, DTXSID40494782, DTXCID40445592, 843-955-6, Pyridine, 2-iodo-4-methyl-, 4-Methyl-2-iodopyridine, MFCD12963767, 2-Iodo-4-picoline, SCHEMBL4008373, XAA28260, AKOS015891955, AS-82640, CS-0436352, D87895, EN300-1666252

Application

2-Iodo-4-methylpyridine serves as a key building block in palladium-catalyzed cross-coupling reactions for drug discovery, particularly in synthesizing kinase inhibitors and antiviral compounds. The iodine moiety enables efficient Sonogashira couplings for alkyne-functionalized heterocycles. In material science, it acts as precursor for N-donor ligands in catalytic systems. The methyl group facilitates C-H activation in late-stage diversification of pharmaceutical intermediates.

Safety and Hazards

GHS Hazard Statements

  • H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
  • H312 (100%): Harmful in contact with skin [Warning Acute toxicity, dermal]
  • H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
  • H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]
  • H332 (100%): Harmful if inhaled [Warning Acute toxicity, inhalation]
  • H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation]

Precautionary Statements

  • P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P317, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501

Hazard Classes and Categories

  • Acute Tox. 4 (100%)
  • Acute Tox. 4 (100%)
  • Skin Irrit. 2 (100%)
  • Eye Irrit. 2A (100%)
  • Acute Tox. 4 (100%)
  • STOT SE 3 (100%)

If you are interested or have any questions, please contact us at support@atomfair.com

Disclaimer: Sold exclusively for laboratory research. Prohibited for commercial use, diagnostics, or human/animal applications. Buyers assume all compliance liability.

Disclaimer

Intended Use & Restrictions

This product is sold exclusively for laboratory research, analytical testing, or non-commercial purposes.

  • Strictly prohibited: Resale, repackaging, or formulation into commercial products.
  • Not approved for human/animal use, diagnostics, or manufacturing (including pharmaceuticals, agrochemicals, or consumer goods).

Patent & Regulatory Compliance

Certain molecules may be protected by active patents or regulatory restrictions.

  • Buyers must independently verify patent status (e.g., via USPTO/EPO/CNIPA) and comply with local laws.
  • Atomfair LLC does not provide legal assurances regarding patent non-infringement or jurisdictional compliance.

Liability Release

By purchasing, the buyer agrees to:

  • Use this product only as permitted by law.
  • Indemnify Atomfair LLC against all claims arising from misuse, patent infringement, or regulatory violations.

Reviews

There are no reviews yet.

Only logged in customers who have purchased this product may leave a review.

Related products