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Atomfair 2-Fluoro-5-(trifluoromethyl)benzaldehyde C8H4F4O

Description 2-Fluoro-5-(trifluoromethyl)benzaldehyde (CAS No. 146137-78-2) is a high-purity fluorinated aromatic aldehyde with the molecular formula C8H4F4O . This compound is a valuable building block in organic synthesis, particularly in pharmaceutical, agrochemical, and material science research. Its unique structure, featuring both fluorine and trifluoromethyl groups, enhances reactivity and stability, making it ideal for nucleophilic substitution reactions, cross-coupling reactions, and as a precursor for heterocyclic compounds. Available in >98% purity (GC), it is supplied in sealed containers under inert gas to ensure stability and longevity. Suitable for use in advanced research, process development, and high-throughput screening applications.

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Description

Description

2-Fluoro-5-(trifluoromethyl)benzaldehyde (CAS No. 146137-78-2) is a high-purity fluorinated aromatic aldehyde with the molecular formula C8H4F4O. This compound is a valuable building block in organic synthesis, particularly in pharmaceutical, agrochemical, and material science research. Its unique structure, featuring both fluorine and trifluoromethyl groups, enhances reactivity and stability, making it ideal for nucleophilic substitution reactions, cross-coupling reactions, and as a precursor for heterocyclic compounds. Available in >98% purity (GC), it is supplied in sealed containers under inert gas to ensure stability and longevity. Suitable for use in advanced research, process development, and high-throughput screening applications.

  • CAS No: 146137-78-2
  • Molecular Formula: C8H4F4O
  • Molecular Weight: 192.11
  • Exact Mass: 192.01982740
  • Monoisotopic Mass: 192.01982740
  • IUPAC Name: 2-fluoro-5-(trifluoromethyl)benzaldehyde
  • SMILES: C1=CC(=C(C=C1C(F)(F)F)C=O)F
  • Synonyms: 2-Fluoro-5-(trifluoromethyl)benzaldehyde, 146137-78-2, DTXSID30370566, DTXCID00321601, 626-370-9

Application

2-Fluoro-5-(trifluoromethyl)benzaldehyde is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals and agrochemicals. Its electron-withdrawing groups make it highly reactive in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings. Researchers also utilize it in the development of liquid crystals, OLED materials, and specialty polymers due to its ability to modify electronic properties. Additionally, it serves as a precursor for bioactive molecules in medicinal chemistry, particularly in the design of enzyme inhibitors and receptor modulators.

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