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Atomfair 2-Fluoro-5-(trifluoromethoxy)aniline C7H5F4NO

Description 2-Fluoro-5-(trifluoromethoxy)aniline (CAS No. 116369-23-4) is a high-purity fluorinated aromatic amine with the molecular formula C7H5F4NO . This specialized compound features a unique trifluoromethoxy (-OCF3) and fluoro (-F) substitution pattern on its aniline core, making it a valuable building block for pharmaceutical, agrochemical, and materials science research. Its electron-withdrawing substituents enhance reactivity in nucleophilic aromatic substitution and cross-coupling reactions. Supplied as a clear to pale yellow liquid (or low-melting solid depending on storage conditions), it is packaged under inert gas to ensure stability. Typical purity ??97% (GC), with exact specifications available in the Certificate of Analysis. Store at 2-8??C in…

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Description

Description

2-Fluoro-5-(trifluoromethoxy)aniline (CAS No. 116369-23-4) is a high-purity fluorinated aromatic amine with the molecular formula C7H5F4NO. This specialized compound features a unique trifluoromethoxy (-OCF3) and fluoro (-F) substitution pattern on its aniline core, making it a valuable building block for pharmaceutical, agrochemical, and materials science research. Its electron-withdrawing substituents enhance reactivity in nucleophilic aromatic substitution and cross-coupling reactions. Supplied as a clear to pale yellow liquid (or low-melting solid depending on storage conditions), it is packaged under inert gas to ensure stability. Typical purity ??97% (GC), with exact specifications available in the Certificate of Analysis. Store at 2-8??C in tightly sealed containers away from light and moisture.

  • CAS No: 116369-23-4
  • Molecular Formula: C7H5F4NO
  • Molecular Weight: 195.11
  • Exact Mass: 195.03072643
  • Monoisotopic Mass: 195.03072643
  • IUPAC Name: 2-fluoro-5-(trifluoromethoxy)aniline
  • SMILES: C1=CC(=C(C=C1OC(F)(F)F)N)F
  • Synonyms: 2-Fluoro-5-(trifluoromethoxy)aniline, 116369-23-4, DTXSID00560295, DTXCID30511073, 640-294-3

Application

This fluorinated aniline derivative serves as a key intermediate in the synthesis of advanced pharmaceutical compounds, particularly those targeting CNS disorders due to its ability to enhance blood-brain barrier penetration. It is widely utilized in Suzuki-Miyaura and Buchwald-Hartwig coupling reactions to construct complex heterocycles. The trifluoromethoxy group’s metabolic stability makes it valuable for developing agrochemicals with improved environmental persistence.

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