Description

Description

2-Bromo-4-fluoroanisole (CAS No. 452-08-4) is a high-purity halogenated anisole derivative with the molecular formula C₇H₆BrFO. This aromatic compound, also known by its IUPAC name 2-bromo-4-fluoro-1-methoxybenzene, features a bromo substituent at the 2-position and a fluoro group at the 4-position of the methoxybenzene ring. Its unique electronic configuration makes it an invaluable building block in pharmaceutical synthesis, particularly for the development of active pharmaceutical ingredients (APIs) and agrochemical intermediates. With a molecular weight of 205.03 g/mol, this reagent is supplied as a clear to pale yellow liquid (or low-melting solid depending on storage conditions) with ??98% purity by GC analysis. Proper storage at 2-8??C under inert atmosphere ensures optimal stability. Suitable for cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig), nucleophilic substitutions, and as a precursor for fluorinated liquid crystals. Available in research (5g, 25g) and bulk quantities (1kg+) with optional certified analytical data.

Application

2-Bromo-4-fluoroanisole serves as a key intermediate in organofluorine chemistry, enabling the synthesis of fluorinated drug candidates through palladium-catalyzed cross-coupling reactions. Its electron-deficient aromatic ring facilitates regioselective functionalization in the development of kinase inhibitors and CNS-active compounds. The compound’s orthogonal halogen/methoxy substitution pattern makes it particularly valuable for constructing axially chiral biaryl systems in asymmetric catalysis. Researchers also utilize this building block in material science for creating fluorinated liquid crystal monomers with tailored dielectric properties.

If you are interested or have any questions, please contact us at support@atomfair.com