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Atomfair 1,2-Difluoro-4-(methylsulfonyl)benzene C7H6F2O2S

Description 1,2-Difluoro-4-(methylsulfonyl)benzene (CAS No. 1535-65-5) is a high-purity aromatic sulfone compound with the molecular formula C7H6F2O2S . This organofluorine building block features a benzene ring substituted with two fluorine atoms at the 1- and 2-positions and a methylsulfonyl group at the 4-position, offering unique electronic and steric properties for advanced synthetic applications. The crystalline solid exhibits excellent thermal stability (mp >150??C) and is supplied with comprehensive analytical documentation including1H/19F NMR, HPLC, and GC-MS purity reports (>98%). Ideal for pharmaceutical intermediates, materials science research, and cross-coupling reactions, this reagent is packaged under inert atmosphere in amber glass vials with PTFE-lined caps…

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Description

Description

1,2-Difluoro-4-(methylsulfonyl)benzene (CAS No. 1535-65-5) is a high-purity aromatic sulfone compound with the molecular formula C7H6F2O2S. This organofluorine building block features a benzene ring substituted with two fluorine atoms at the 1- and 2-positions and a methylsulfonyl group at the 4-position, offering unique electronic and steric properties for advanced synthetic applications. The crystalline solid exhibits excellent thermal stability (mp >150??C) and is supplied with comprehensive analytical documentation including 1H/19F NMR, HPLC, and GC-MS purity reports (>98%). Ideal for pharmaceutical intermediates, materials science research, and cross-coupling reactions, this reagent is packaged under inert atmosphere in amber glass vials with PTFE-lined caps to ensure long-term stability. Special handling recommendations include storage at 2-8??C in a dry environment and use of appropriate PPE due to potential irritant properties.

  • CAS No: 1535-65-5
  • Molecular Formula: C7H6F2O2S
  • Molecular Weight: 192.19
  • Exact Mass: 192.00565693
  • Monoisotopic Mass: 192.00565693
  • IUPAC Name: 1,2-difluoro-4-methylsulfonylbenzene
  • SMILES: CS(=O)(=O)C1=CC(=C(C=C1)F)F
  • Synonyms: 1,2-Difluoro-4-(methylsulfonyl)benzene, 424792-57-4, DTXSID20382259, DTXCID00333284, 674-385-4

Application

This fluorinated sulfone derivative serves as a versatile intermediate in medicinal chemistry for the development of kinase inhibitors and other bioactive molecules. The electron-withdrawing sulfonyl group activates the aromatic ring for nucleophilic aromatic substitution reactions, while the fluorine substituents enable selective functionalization. Researchers utilize this compound in materials science for designing high-performance polymers with enhanced thermal and chemical resistance. It also finds application as a precursor for liquid crystal materials and as a building block in Pd-catalyzed cross-coupling reactions.

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