Description

Description

1-Ethoxy-2,3-difluoro-4-iodobenzene (CAS No. 144292-42-2) is a high-purity fluorinated aromatic compound with the molecular formula C₈H₇F₂IO. This specialized chemical is designed for advanced research and industrial applications, featuring an ethoxy group and iodine substitution on a difluorobenzene backbone. Its unique structure makes it a valuable intermediate in organic synthesis, particularly in pharmaceutical development, agrochemical research, and materials science. The compound is supplied with comprehensive analytical data including ¹H NMR, ¹³C NMR, and mass spectrometry verification to ensure quality and consistency. Available in various quantities with strict purity standards (typically ??95% by GC analysis), it is packaged under inert atmosphere to maintain stability. Suitable for use in cross-coupling reactions, nucleophilic substitutions, and as a building block for more complex fluorinated compounds.

Application

1-Ethoxy-2,3-difluoro-4-iodobenzene serves as a versatile intermediate in pharmaceutical synthesis, particularly for introducing fluorine-containing aromatic moieties into drug candidates. Its reactive iodine position enables participation in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, or Sonogashira couplings) for creating biaryl structures. The compound finds use in material science for developing liquid crystals and fluorinated polymers with enhanced thermal stability. Researchers also employ it as a precursor for synthesizing fluorinated ligands in catalytic systems.

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