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Atomfair Camptothecin C20H16N2O4

Description Camptothecin (CAS 1480-64-4) is a potent quinoline alkaloid with the molecular formula C20H16N2O4. It is a naturally occurring compound derived from the bark of the Chinese tree Camptotheca acuminata . This topoisomerase I inhibitor exhibits significant antitumor activity by stabilizing the DNA-topoisomerase I complex, leading to DNA damage and apoptosis in rapidly dividing cells. Camptothecin is widely utilized in cancer research, pharmaceutical development, and biochemical studies due to its unique mechanism of action. Available in high-purity form (>98%), it is ideal for in vitro and in vivo applications. Store at -20??C in a dry, dark environment to maintain stability.

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Description

Description

Camptothecin (CAS 1480-64-4) is a potent quinoline alkaloid with the molecular formula C20H16N2O4. It is a naturally occurring compound derived from the bark of the Chinese tree Camptotheca acuminata. This topoisomerase I inhibitor exhibits significant antitumor activity by stabilizing the DNA-topoisomerase I complex, leading to DNA damage and apoptosis in rapidly dividing cells. Camptothecin is widely utilized in cancer research, pharmaceutical development, and biochemical studies due to its unique mechanism of action. Available in high-purity form (>98%), it is ideal for in vitro and in vivo applications. Store at -20??C in a dry, dark environment to maintain stability.

  • CAS No: 1480-64-4
  • Molecular Formula: C20H16N2O4
  • Molecular Weight: 348.4
  • Exact Mass: 348.11100700
  • Monoisotopic Mass: 348.11100700
  • IUPAC Name: (19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
  • SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
  • Synonyms: camptothecin, Camptothecine, 7689-03-4, (S)-(+)-Camptothecin, (+)-Camptothecin

Application

Camptothecin is primarily used in oncology research as a topoisomerase I inhibitor, inducing DNA strand breaks and apoptosis in cancer cells. It serves as a reference compound for studying chemotherapeutic agents and drug resistance mechanisms. Researchers also employ it in biochemical assays to investigate DNA replication and repair pathways. Additionally, its derivatives (e.g., irinotecan, topotecan) are clinically approved for treating colorectal and ovarian cancers.

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