Description

Description

3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid (CAS No. 80194-68-9) is a high-purity fluorinated pyridine derivative with the molecular formula C₇H₃ClF₃NO₂. This compound features a trifluoromethyl group and a carboxylic acid moiety on a chlorinated pyridine backbone, making it a versatile intermediate for pharmaceutical, agrochemical, and materials science research. Its unique structure enables applications in the synthesis of bioactive molecules, including potential drug candidates and crop protection agents. Available in >98% purity (HPLC), this product is supplied as a white to off-white crystalline powder with strict quality control to ensure batch-to-batch consistency. Store in a cool, dry place under inert conditions to maintain stability. Suitable for use in cross-coupling reactions, carboxylate derivatization, and as a building block for heterocyclic compounds.

Application

3-Chloro-5-(trifluoromethyl)pyridine-2-carboxylic acid is a key intermediate in the synthesis of trifluoromethyl-substituted pyridine derivatives, which are widely used in pharmaceutical and agrochemical research. The compound’s reactive carboxylic acid group allows for further functionalization, making it valuable for designing novel active ingredients. Its trifluoromethyl group enhances lipophilicity and metabolic stability, a desirable trait in drug discovery. Researchers also utilize it to develop ligands for catalysis and advanced materials.

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