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Atomfair Carmofur C11H16FN3O3

Description Carmofur (CAS No. 6140-17-6) is a fluorinated pyrimidine analog with the molecular formula C11H16FN3O3and the IUPAC name 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide . This compound is a well-characterized antineoplastic agent that functions as a prodrug of 5-fluorouracil (5-FU), exhibiting potent inhibitory effects on thymidylate synthase and subsequent DNA synthesis. Carmofur is supplied as a high-purity (>98%) white to off-white crystalline powder, meticulously analyzed via HPLC, NMR, and mass spectrometry to ensure batch-to-batch consistency. It is soluble in DMSO and ethanol but exhibits limited aqueous solubility. Suitable for research applications in oncology, enzymology, and drug metabolism studies, this product is packaged under inert conditions…

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Description

Description

Carmofur (CAS No. 6140-17-6) is a fluorinated pyrimidine analog with the molecular formula C11H16FN3O3 and the IUPAC name 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide. This compound is a well-characterized antineoplastic agent that functions as a prodrug of 5-fluorouracil (5-FU), exhibiting potent inhibitory effects on thymidylate synthase and subsequent DNA synthesis. Carmofur is supplied as a high-purity (>98%) white to off-white crystalline powder, meticulously analyzed via HPLC, NMR, and mass spectrometry to ensure batch-to-batch consistency. It is soluble in DMSO and ethanol but exhibits limited aqueous solubility. Suitable for research applications in oncology, enzymology, and drug metabolism studies, this product is packaged under inert conditions to guarantee stability. Synonyms include Mifurol, Yamaful, and 1-Hexylcarbamoyl-5-fluorouracil.

  • CAS No: 6140-17-6
  • Molecular Formula: C11H16FN3O3
  • Molecular Weight: 257.26
  • Exact Mass: 257.11756954
  • Monoisotopic Mass: 257.11756954
  • IUPAC Name: 5-fluoro-N-hexyl-2,4-dioxopyrimidine-1-carboxamide
  • SMILES: CCCCCCNC(=O)N1C=C(C(=O)NC1=O)F
  • Synonyms: carmofur, 61422-45-5, Mifurol, Yamaful, 1-Hexylcarbamoyl-5-fluorouracil

Application

Carmofur is primarily utilized in biochemical and cancer research as a fluoropyrimidine derivative that metabolizes into 5-fluorouracil (5-FU), inhibiting thymidylate synthase and disrupting DNA/RNA synthesis in proliferating cells. It has been investigated for its efficacy against colorectal, breast, and gastric carcinomas in preclinical models. Researchers also employ carmofur to study drug resistance mechanisms and combination therapies with other antimetabolites. Its lipophilic hexylcarbamoyl moiety enhances cellular uptake compared to 5-FU, making it valuable for pharmacokinetic studies.

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