Description

Description

2,4,5-Trifluoroiodobenzene (CAS No. 459424-72-7) is a high-purity halogenated aromatic compound with the molecular formula C₆H₂F₃I. This specialized chemical is widely utilized in advanced organic synthesis, particularly in pharmaceutical and agrochemical research. Its IUPAC name, 1,2,4-trifluoro-5-iodobenzene, reflects its precise structural configuration featuring three fluorine substituents and an iodine atom on a benzene ring, offering unique reactivity for cross-coupling reactions such as Suzuki-Miyaura and Ullmann couplings.

Our product is rigorously tested to ensure ??98% purity (GC) and is supplied in sealed, light-resistant packaging to prevent degradation. Ideal for use as a versatile building block in medicinal chemistry, 2,4,5-Trifluoroiodobenzene enables the introduction of trifluoromethyl groups and iodine moieties into complex molecules. Researchers value its stability and predictable reactivity in nucleophilic aromatic substitution (S_NAr) reactions and transition metal-catalyzed transformations.

Available in quantities from 1g to 1kg, this compound is handled in controlled environments to maintain integrity. SDS and analytical certificates (CoA) are provided with every order. Store under inert atmosphere at 2-8??C for optimal shelf life.

Application

2,4,5-Trifluoroiodobenzene serves as a critical intermediate in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for antidepressants and antiviral agents. Its iodine moiety facilitates palladium-catalyzed cross-coupling reactions to construct biaryl systems in drug discovery. The compound is also employed in material science to create liquid crystals and fluorinated polymers with enhanced thermal stability. In agrochemical research, it functions as a precursor for herbicides and pesticides with improved environmental persistence.

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