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Atomfair H-alpha-Me-D-Phe(3-I)-OH C10H12INO2

Description H-alpha-Me-D-Phe(3-I)-OH ( CAS 457653-01-9 ) is a high-purity, non-natural amino acid derivative with the molecular formula C10H12INO2. This compound, systematically named (2R)-2-amino-3-(3-iodophenyl)-2-methylpropanoic acid , features a stereospecific D-configuration and an alpha-methyl substitution, enhancing its metabolic stability for peptide modification applications. The 3-iodophenyl moiety provides a versatile handle for further functionalization via cross-coupling reactions. Supplied as a white to off-white crystalline powder with ??95% purity (HPLC), this building block is ideal for solid-phase peptide synthesis (SPPS), Fmoc/t-Boc strategies, and medicinal chemistry research. Each batch undergoes rigorous QC including1H/13C NMR, MS, and chiral HPLC analysis to ensure optimal performance in your…

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Description

Description

H-alpha-Me-D-Phe(3-I)-OH (CAS 457653-01-9) is a high-purity, non-natural amino acid derivative with the molecular formula C10H12INO2. This compound, systematically named (2R)-2-amino-3-(3-iodophenyl)-2-methylpropanoic acid, features a stereospecific D-configuration and an alpha-methyl substitution, enhancing its metabolic stability for peptide modification applications. The 3-iodophenyl moiety provides a versatile handle for further functionalization via cross-coupling reactions. Supplied as a white to off-white crystalline powder with ??95% purity (HPLC), this building block is ideal for solid-phase peptide synthesis (SPPS), Fmoc/t-Boc strategies, and medicinal chemistry research. Each batch undergoes rigorous QC including 1H/13C NMR, MS, and chiral HPLC analysis to ensure optimal performance in your applications.

  • CAS No: 457653-01-9
  • Molecular Formula: C10H12INO2
  • Molecular Weight: 305.11
  • Exact Mass: 304.99128
  • Monoisotopic Mass: 304.99128
  • IUPAC Name: (2R)-2-amino-3-(3-iodophenyl)-2-methylpropanoic acid
  • SMILES: C[C@@](CC1=CC(=CC=C1)I)(C(=O)O)N
  • Synonyms: 457652-83-4, H-alpha-Me-D-Phe(3-I)-OH, DTXSID10438693, DTXCID10389515, (2R)-2-amino-3-(3-iodophenyl)-2-methylpropanoic acid

Application

This iodinated phenylalanine derivative serves as a key intermediate in designing radiolabeled peptides for PET imaging probes targeting neuroendocrine tumors. Researchers employ it to create protease-resistant peptide analogs in metabolic disorder studies due to its ??-methyl stabilization. The iodine atom facilitates click chemistry modifications for bioconjugation in antibody-drug conjugate (ADC) development.

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