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Atomfair H-alpha-Me-D-Phe(3-I)-OH C10H12INO2

Description H-alpha-Me-D-Phe(3-I)-OH ( CAS 457652-83-4 ) is a high-purity, non-natural amino acid derivative designed for advanced research and pharmaceutical applications. This compound features a stereospecific (R)-configuration at the alpha-carbon, a methyl group substitution, and a 3-iodophenyl side chain, offering unique steric and electronic properties for peptide modification and medicinal chemistry studies. With the molecular formula C10H12INO2and a molar mass of 305.11 g/mol, it is supplied as a white to off-white crystalline powder with ??95% purity (HPLC). Ideal for solid-phase peptide synthesis (SPPS), it enhances resistance to enzymatic degradation and modulates peptide conformation. Store under inert conditions at -20??C to ensure…

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Description

Description

H-alpha-Me-D-Phe(3-I)-OH (CAS 457652-83-4) is a high-purity, non-natural amino acid derivative designed for advanced research and pharmaceutical applications. This compound features a stereospecific (R)-configuration at the alpha-carbon, a methyl group substitution, and a 3-iodophenyl side chain, offering unique steric and electronic properties for peptide modification and medicinal chemistry studies. With the molecular formula C10H12INO2 and a molar mass of 305.11 g/mol, it is supplied as a white to off-white crystalline powder with ??95% purity (HPLC). Ideal for solid-phase peptide synthesis (SPPS), it enhances resistance to enzymatic degradation and modulates peptide conformation. Store under inert conditions at -20??C to ensure stability. Suitable for in vitro and in vivo research applications.

  • CAS No: 457652-83-4
  • Molecular Formula: C10H12INO2
  • Molecular Weight: 305.11
  • Exact Mass: 304.99128
  • Monoisotopic Mass: 304.99128
  • IUPAC Name: (2R)-2-amino-3-(3-iodophenyl)-2-methylpropanoic acid
  • SMILES: C[C@@](CC1=CC(=CC=C1)I)(C(=O)O)N
  • Synonyms: 457652-83-4, H-alpha-Me-D-Phe(3-I)-OH, DTXSID10438693, DTXCID10389515, (2R)-2-amino-3-(3-iodophenyl)-2-methylpropanoic acid

Application

H-alpha-Me-D-Phe(3-I)-OH is primarily used in peptide engineering to introduce iodinated aromatic motifs for radiolabeling or structural studies. Its methylated alpha-carbon restricts backbone flexibility, making it valuable for probing receptor-binding interactions in drug discovery. The iodine atom enables potential applications in PET imaging or as a heavy-atom derivative for X-ray crystallography.

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