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Atomfair 2-Bromo-1-chloro-4-(trifluoromethyl)benzene C7H3BrClF3

Description 2-Bromo-1-chloro-4-(trifluoromethyl)benzene (CAS No. 454-78-4) is a high-purity halogenated aromatic compound with the molecular formula C7H3BrClF3. This versatile intermediate is widely used in pharmaceutical, agrochemical, and material science research due to its reactive bromo and chloro substituents, as well as its electron-withdrawing trifluoromethyl group. The compound is supplied as a clear to pale-yellow liquid with a purity of ??98% (GC), ensuring consistent performance in synthetic applications. Its well-defined structure makes it ideal for Suzuki couplings, nucleophilic substitutions, and other cross-coupling reactions. Proper storage under inert atmosphere at 2-8??C is recommended to maintain stability.

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Description

Description

2-Bromo-1-chloro-4-(trifluoromethyl)benzene (CAS No. 454-78-4) is a high-purity halogenated aromatic compound with the molecular formula C7H3BrClF3. This versatile intermediate is widely used in pharmaceutical, agrochemical, and material science research due to its reactive bromo and chloro substituents, as well as its electron-withdrawing trifluoromethyl group. The compound is supplied as a clear to pale-yellow liquid with a purity of ??98% (GC), ensuring consistent performance in synthetic applications. Its well-defined structure makes it ideal for Suzuki couplings, nucleophilic substitutions, and other cross-coupling reactions. Proper storage under inert atmosphere at 2-8??C is recommended to maintain stability.

  • CAS No: 454-78-4
  • Molecular Formula: C7H3BrClF3
  • Molecular Weight: 259.45
  • Exact Mass: 257.90587
  • Monoisotopic Mass: 257.90587
  • IUPAC Name: 2-bromo-1-chloro-4-(trifluoromethyl)benzene
  • SMILES: C1=CC(=C(C=C1C(F)(F)F)Br)Cl
  • Synonyms: 2-Bromo-1-chloro-4-(trifluoromethyl)benzene, EINECS 207-226-0, APSISOSWYXCEQX-UHFFFAOYSA-, DTXSID80196495, NSC 59728

Application

2-Bromo-1-chloro-4-(trifluoromethyl)benzene serves as a key building block in the synthesis of active pharmaceutical ingredients (APIs) and specialty chemicals. Researchers utilize this compound to introduce trifluoromethylphenyl motifs into target molecules, enhancing their metabolic stability and lipophilicity. It’s particularly valuable in developing crop protection agents and electronic materials where halogenated aromatics are required. The simultaneous presence of bromo and chloro substituents allows for selective functionalization in multi-step syntheses.

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