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Atomfair 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine C11H15BFNO2

Description 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS: 444120-95-0) is a high-purity boronic ester derivative widely used in Suzuki-Miyaura cross-coupling reactions and other palladium-catalyzed transformations. With the molecular formula C11H15BFNO2, this compound features a stable pinacol boronate group coupled with a fluoropyridine moiety, making it an essential building block for pharmaceutical, agrochemical, and materials science research. Its robust stability under various reaction conditions ensures reliable performance in complex synthetic pathways. Offered as a crystalline solid or solution, this reagent is rigorously tested via HPLC, NMR, and mass spectrometry to guarantee ??95% purity, meeting the stringent demands of modern organic synthesis.

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Description

Description

2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS: 444120-95-0) is a high-purity boronic ester derivative widely used in Suzuki-Miyaura cross-coupling reactions and other palladium-catalyzed transformations. With the molecular formula C11H15BFNO2, this compound features a stable pinacol boronate group coupled with a fluoropyridine moiety, making it an essential building block for pharmaceutical, agrochemical, and materials science research. Its robust stability under various reaction conditions ensures reliable performance in complex synthetic pathways. Offered as a crystalline solid or solution, this reagent is rigorously tested via HPLC, NMR, and mass spectrometry to guarantee ??95% purity, meeting the stringent demands of modern organic synthesis.

  • CAS No: 444120-95-0
  • Molecular Formula: C11H15BFNO2
  • Molecular Weight: 223.05
  • Exact Mass: 223.1179870
  • Monoisotopic Mass: 223.1179870
  • IUPAC Name: 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CN=C(C=C2)F
  • Synonyms: 444120-95-0, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine, 2-Fluoropyridine-5-boronic acid pinacol ester, 6-Fluoropyridine-3-boronic acid, pinacol ester, 6-FLUOROPYRIDINE-3-BORONIC ACID PINACOL ESTER

Application

This compound is primarily employed in Suzuki-Miyaura cross-coupling reactions to introduce fluoropyridine motifs into target molecules, enabling the synthesis of bioactive compounds and functional materials. It serves as a key intermediate in the development of pharmaceuticals, particularly kinase inhibitors and PET radiotracers. The fluorine substituent enhances metabolic stability and binding affinity in drug candidates, while the boronate group facilitates efficient C-C bond formation under mild conditions.

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