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Atomfair 2-Bromo-3-fluoropyridine C5H3BrFN

Description 2-Bromo-3-fluoropyridine (CAS No. 40273-45-8) is a high-purity halogenated pyridine derivative with the molecular formula C5H3BrFN . This heteroaromatic compound is a versatile building block in pharmaceutical, agrochemical, and materials science research. Its unique structure, featuring both bromine and fluorine substituents on the pyridine ring, enables selective functionalization via cross-coupling reactions (e.g., Suzuki, Stille) or nucleophilic substitutions. Available in ??98% purity (GC), it is supplied as a clear to pale-yellow liquid with strict quality control via HPLC, NMR, and GC-MS analysis. Store under inert atmosphere at 2-8??C to maintain stability. Suitable for use in high-throughput screening, medicinal chemistry, and as…

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Description

Description

2-Bromo-3-fluoropyridine (CAS No. 40273-45-8) is a high-purity halogenated pyridine derivative with the molecular formula C5H3BrFN. This heteroaromatic compound is a versatile building block in pharmaceutical, agrochemical, and materials science research. Its unique structure, featuring both bromine and fluorine substituents on the pyridine ring, enables selective functionalization via cross-coupling reactions (e.g., Suzuki, Stille) or nucleophilic substitutions. Available in ??98% purity (GC), it is supplied as a clear to pale-yellow liquid with strict quality control via HPLC, NMR, and GC-MS analysis. Store under inert atmosphere at 2-8??C to maintain stability. Suitable for use in high-throughput screening, medicinal chemistry, and as a precursor for fluorinated liquid crystals or ligands.

  • CAS No: 40273-45-8
  • Molecular Formula: C5H3BrFN
  • Molecular Weight: 175.99
  • Exact Mass: 174.94329
  • Monoisotopic Mass: 174.94329
  • IUPAC Name: 2-bromo-3-fluoropyridine
  • SMILES: C1=CC(=C(N=C1)Br)F
  • Synonyms: 2-Bromo-3-fluoropyridine, 40273-45-8, DTXSID10376465, DTXCID70327493, 675-562-9

Application

2-Bromo-3-fluoropyridine serves as a key intermediate in the synthesis of fluorinated pharmaceuticals, particularly kinase inhibitors and CNS-targeting compounds. Its bromine moiety facilitates palladium-catalyzed couplings for constructing complex heterocycles, while the fluorine enhances metabolic stability in drug candidates. Researchers also employ it to develop agrochemicals and electronic materials requiring halogenated pyridine cores. The compound’s reactivity is exploited in Suzuki-Miyaura and Buchwald-Hartwig amination reactions.

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