Description

Description

2-(4-Fluoro-2-nitrophenyl)acetic acid (CAS No. 39616-95-0) is a high-purity aromatic carboxylic acid derivative with the molecular formula C₈H₆FNO₄. This compound features a fluoro-substituted nitrophenyl group attached to an acetic acid moiety, making it a valuable intermediate in organic synthesis and pharmaceutical research. With a molecular weight of 199.14 g/mol, it is supplied as a fine crystalline powder or solid, ensuring consistent reactivity and solubility in common organic solvents. Ideal for researchers and scientists, this product is rigorously tested for purity (typically ??95-98% by HPLC or GC analysis) and is packaged under inert conditions to maintain stability. Suitable for use in peptide coupling, heterocycle synthesis, and as a building block for fluorinated active pharmaceutical ingredients (APIs).

Application

2-(4-Fluoro-2-nitrophenyl)acetic acid is widely employed as a key synthetic intermediate in medicinal chemistry for the development of fluorinated drug candidates. Its reactive carboxyl group enables facile conjugation to amines or alcohols via ester/amide formation, while the nitro group serves as a precursor for reduced aniline derivatives. This compound is particularly useful in the synthesis of protease inhibitors, kinase modulators, and other bioactive molecules targeting CNS disorders. Researchers also utilize it in material science for designing fluorinated polymers with enhanced thermal stability.

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