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Atomfair 4-Fluoroiodobenzene C6H4FI

Description 4-Fluoroiodobenzene (CAS No. 352-34-1) is a high-purity halogenated aromatic compound with the molecular formula C6H4FI . This organoiodine reagent, also known by its IUPAC name 1-fluoro-4-iodobenzene , features a fluorine atom and an iodine atom in para positions on the benzene ring, making it a versatile building block for synthetic organic chemistry. The compound is supplied as a clear to pale yellow liquid with exceptional purity (>98%) suitable for nucleophilic substitution reactions, cross-coupling reactions (e.g., Suzuki, Stille, or Sonogashira couplings), and as a precursor for pharmaceuticals and advanced materials. Proper storage under inert atmosphere at 2-8??C is recommended to…

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Description

Description

4-Fluoroiodobenzene (CAS No. 352-34-1) is a high-purity halogenated aromatic compound with the molecular formula C6H4FI. This organoiodine reagent, also known by its IUPAC name 1-fluoro-4-iodobenzene, features a fluorine atom and an iodine atom in para positions on the benzene ring, making it a versatile building block for synthetic organic chemistry. The compound is supplied as a clear to pale yellow liquid with exceptional purity (>98%) suitable for nucleophilic substitution reactions, cross-coupling reactions (e.g., Suzuki, Stille, or Sonogashira couplings), and as a precursor for pharmaceuticals and advanced materials. Proper storage under inert atmosphere at 2-8??C is recommended to maintain stability. All batches are QC-verified by GC-MS and NMR spectroscopy.

  • CAS No: 352-34-1
  • Molecular Formula: C6H4FI
  • Molecular Weight: 222.00
  • Exact Mass: 221.93418
  • Monoisotopic Mass: 221.93418
  • IUPAC Name: 1-fluoro-4-iodobenzene
  • SMILES: C1=CC(=CC=C1F)I
  • Synonyms: 4-Fluoroiodobenzene, 1-FLUORO-4-IODOBENZENE, p-Fluoroiodobenzene, Benzene, 1-fluoro-4-iodo-, 4-fluoro-1-iodobenzene

Application

4-Fluoroiodobenzene serves as a key intermediate in pharmaceutical synthesis, particularly for fluorinated active pharmaceutical ingredients (APIs). The compound is widely used in palladium-catalyzed cross-coupling reactions to create biaryl structures in medicinal chemistry. Researchers also employ it as a fluorinated building block in materials science for liquid crystals and organic electronic materials. The iodine moiety provides an excellent handle for further functionalization through metal-catalyzed reactions.

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