Description

Description

4-Fluorobenzenesulfonyl chloride (CAS No. 349-88-2) is a high-purity organosulfur compound with the molecular formula C₆H₄ClFO₂S. This reactive intermediate is widely utilized in organic synthesis, particularly in the preparation of sulfonamides and sulfonate esters. The compound features a fluorinated aromatic ring coupled with a highly electrophilic sulfonyl chloride group, making it an essential reagent for introducing the 4-fluorobenzenesulfonyl moiety into target molecules. It is supplied as a clear to pale yellow liquid (or crystalline solid, depending on storage conditions) with a characteristic pungent odor. Suitable for use under inert conditions, this chemical is rigorously tested for purity (typically ??97% by GC or HPLC) and is packaged in amber glass bottles to ensure stability. Ideal for pharmaceutical, agrochemical, and materials science research.

Application

4-Fluorobenzenesulfonyl chloride is primarily employed as a key building block in the synthesis of sulfonamide derivatives, which are prevalent in drug discovery (e.g., antibacterial and antiviral agents). It also serves as a precursor for functionalized polymers and specialty chemicals requiring fluorinated sulfonyl groups. In materials science, it is used to modify surface properties or create sulfonated fluorinated monomers.

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