Description

Description

4-Chloro-3-(trifluoromethyl)benzyl bromide (CAS No. 261763-23-9) is a high-purity halogenated aromatic compound with the molecular formula C₈H₅BrClF₃. This organobromine reagent is a versatile building block in synthetic organic chemistry, particularly for nucleophilic substitution reactions and cross-coupling methodologies. The presence of both bromomethyl and chloro substituents on the benzene ring, along with the electron-withdrawing trifluoromethyl group, makes it an excellent electrophile for C-C bond formation. Supplied as a clear to pale yellow liquid (or low-melting solid depending on storage conditions), it is moisture-sensitive and should be handled under inert atmosphere. Ideal for pharmaceutical intermediates, agrochemical synthesis, and material science applications requiring selective functionalization. Purity is typically ??95% by GC or HPLC analysis. Store at 2-8??C in amber glass under argon.

Application

This compound serves as a key intermediate in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions for biaryl synthesis. The bromomethyl group readily participates in nucleophilic substitutions to create benzyl ethers, amines, or thioethers in medicinal chemistry applications. Its electron-deficient aromatic system makes it valuable for constructing liquid crystal materials and OLED precursors. Researchers also utilize it in the development of CF₃-containing bioactive molecules for drug discovery programs.

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