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Atomfair 2-(Bromomethyl)-4-chloro-1-(trifluoromethyl)benzene 5-Chloro-2-(trifluoromethyl)benzyl bromide C8H5BrClF3

Description 2-(Bromomethyl)-4-chloro-1-(trifluoromethyl)benzene (CAS No. 261763-22-8) is a high-purity halogenated aromatic compound with the molecular formula C8H5BrClF3. This versatile intermediate features a reactive bromomethyl group and electron-withdrawing chloro- and trifluoromethyl substituents, making it ideal for nucleophilic substitutions, cross-coupling reactions, and as a building block in pharmaceutical and agrochemical synthesis. Supplied as a clear to pale-yellow liquid (or low-melting solid) with ??95% purity (GC), it is packaged under inert gas to ensure stability. Compatible with Grignard reactions, Suzuki couplings, and other organometallic transformations. Store at 2-8??C in a tightly sealed container away from moisture and light. Available in research (5g, 25g) and…

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Description

Description

2-(Bromomethyl)-4-chloro-1-(trifluoromethyl)benzene (CAS No. 261763-22-8) is a high-purity halogenated aromatic compound with the molecular formula C8H5BrClF3. This versatile intermediate features a reactive bromomethyl group and electron-withdrawing chloro- and trifluoromethyl substituents, making it ideal for nucleophilic substitutions, cross-coupling reactions, and as a building block in pharmaceutical and agrochemical synthesis. Supplied as a clear to pale-yellow liquid (or low-melting solid) with ??95% purity (GC), it is packaged under inert gas to ensure stability. Compatible with Grignard reactions, Suzuki couplings, and other organometallic transformations. Store at 2-8??C in a tightly sealed container away from moisture and light. Available in research (5g, 25g) and bulk quantities (100g, 1kg) with optional COA and NMR data.

  • CAS No: 261763-22-8
  • Molecular Formula: C8H5BrClF3
  • Molecular Weight: 273.48
  • Exact Mass: 271.92152
  • Monoisotopic Mass: 271.92152
  • IUPAC Name: 2-(bromomethyl)-4-chloro-1-(trifluoromethyl)benzene
  • SMILES: C1=CC(=C(C=C1Cl)CBr)C(F)(F)F
  • Synonyms: 2-(bromomethyl)-4-chloro-1-(trifluoromethyl)benzene, 5-Chloro-2-(trifluoromethyl)benzyl bromide, 261763-24-0, Benzene, 2-(bromomethyl)-4-chloro-1-(trifluoromethyl)-, 5-Chloro-2(Trifluoromethyl)Benzyl Bromide

Application

This compound serves as a key intermediate in the synthesis of trifluoromethyl-substituted pharmaceuticals, particularly kinase inhibitors and anti-inflammatory agents. Its reactive benzyl bromide moiety enables facile derivatization for structure-activity relationship (SAR) studies in drug discovery. The chloro and trifluoromethyl groups enhance metabolic stability in bioactive molecules, making it valuable for agrochemical development. Also used in materials science for constructing fluorinated liquid crystals and OLED precursors.

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