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Atomfair 4-N-butyl-6-[[4-[(dimethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine D18, HY-144501 C21H28N6

Description 4-N-butyl-6-[[4-[(dimethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine (CAS No. 2433725-54-1) is a high-purity synthetic organic compound with the molecular formula C21H28N6. This pyrido[3,2-d]pyrimidine derivative features a butylamine substituent at the 4-position and a dimethylaminomethylbenzyl group at the 6-position, making it a valuable intermediate for pharmaceutical research and medicinal chemistry applications. The compound is supplied as a lyophilized powder with ??95% purity (HPLC) and is rigorously characterized by1H NMR,13C NMR, and LC-MS to ensure batch-to-batch consistency. Suitable for use in kinase inhibition studies, drug discovery programs, and structure-activity relationship (SAR) investigations. Store at -20??C under inert atmosphere to maintain stability.

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Description

Description

4-N-butyl-6-[[4-[(dimethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine (CAS No. 2433725-54-1) is a high-purity synthetic organic compound with the molecular formula C21H28N6. This pyrido[3,2-d]pyrimidine derivative features a butylamine substituent at the 4-position and a dimethylaminomethylbenzyl group at the 6-position, making it a valuable intermediate for pharmaceutical research and medicinal chemistry applications. The compound is supplied as a lyophilized powder with ??95% purity (HPLC) and is rigorously characterized by 1H NMR, 13C NMR, and LC-MS to ensure batch-to-batch consistency. Suitable for use in kinase inhibition studies, drug discovery programs, and structure-activity relationship (SAR) investigations. Store at -20??C under inert atmosphere to maintain stability.

  • CAS No: 2433725-54-1
  • Molecular Formula: C21H28N6
  • Molecular Weight: 364.5
  • Exact Mass: 364.23754492
  • Monoisotopic Mass: 364.23754492
  • IUPAC Name: 4-N-butyl-6-[[4-[(dimethylamino)methyl]phenyl]methyl]pyrido[3,2-d]pyrimidine-2,4-diamine
  • SMILES: CCCCNC1=NC(=NC2=C1N=C(C=C2)CC3=CC=C(C=C3)CN(C)C)N
  • Synonyms: CHEMBL5077799, D18, 2230218-36-5, BDBM50581908, HY-144501

Application

This compound serves as a key scaffold in the development of kinase inhibitors, particularly for cancer research applications. The dimethylaminomethylbenzyl moiety enhances cellular permeability, while the pyrido[3,2-d]pyrimidine core provides optimal geometry for ATP-binding site interactions. Researchers utilize this building block for targeted drug discovery against tyrosine kinase-dependent pathways. It has shown preliminary activity in biochemical screening assays related to angiogenesis inhibition.

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