Description

Description

4,4-Difluorocyclohexanone (CAS No. 22515-18-0) is a high-purity fluorinated cyclic ketone with the molecular formula C₆H₈F₂O. This compound, also known by its IUPAC name 4,4-difluorocyclohexan-1-one, is a valuable building block in organic synthesis and pharmaceutical research. Its unique structure, featuring two fluorine atoms at the 4-position of the cyclohexanone ring, enhances its reactivity and utility in nucleophilic substitution reactions, carbonyl chemistry, and as a precursor for fluorinated intermediates. Suitable for use in medicinal chemistry, material science, and agrochemical applications, our 4,4-Difluorocyclohexanone is rigorously tested to ensure ??98% purity (GC) and is supplied in sealed containers under inert atmosphere to maintain stability. Available in quantities from grams to kilograms, this product is ideal for researchers seeking reliable fluorinated synthons.

Application

4,4-Difluorocyclohexanone serves as a versatile intermediate in the synthesis of fluorinated pharmaceuticals, agrochemicals, and specialty materials. Its carbonyl group enables reactions such as Grignard additions, reductive aminations, and condensations, while the difluoro substitution enhances metabolic stability in drug candidates. This compound is particularly useful in the development of kinase inhibitors, anti-inflammatory agents, and fluorinated liquid crystals for display technologies. Researchers also employ it to study the effects of fluorine substitution on cyclohexane ring conformation and reactivity.

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