Description

Description

4-Fluoro-2-(trifluoromethyl)phenylacetonitrile (CAS No. 220239-65-6) is a high-purity fluorinated aromatic nitrile compound with the molecular formula C₉H₅F₄N. This specialty chemical is characterized by its unique trifluoromethyl and fluoro substituents on the phenyl ring, which enhance its reactivity and utility in advanced synthetic applications. It is supplied as a clear to pale-yellow liquid or low-melting solid with a molecular weight of 203.14 g/mol. The compound is rigorously tested for quality (typically ??95% purity by GC/HPLC) and is ideal for pharmaceutical intermediates, agrochemical synthesis, and materials science research. Store under inert atmosphere at 2-8??C to maintain stability.

Key Features:

• IUPAC Name: 2-[4-fluoro-2-(trifluoromethyl)phenyl]acetonitrile
• Synonyms include 2-Trifluoromethyl-4-fluorobenzyl cyanide
• Highly reactive nitrile group for nucleophilic substitutions
• Fluorinated aromatic backbone for enhanced lipophilicity
• Compatible with Suzuki coupling, cyanation, and other cross-coupling reactions

Application

4-Fluoro-2-(trifluoromethyl)phenylacetonitrile serves as a versatile building block in medicinal chemistry for the synthesis of fluorinated heterocycles and bioactive molecules. Its electron-withdrawing trifluoromethyl group makes it valuable in designing kinase inhibitors and CNS-active compounds. The nitrile functionality allows further transformations into carboxylic acids, amides, or tetrazoles. Researchers also utilize it in material science to develop liquid crystals and fluorinated polymers with enhanced thermal stability.

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