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Atomfair 3′,4′,5′-Trifluoroacetophenone C8H5F3O

Description 3′,4′,5′-Trifluoroacetophenone (CAS No. 220141-73-1) is a high-purity fluorinated aromatic ketone with the molecular formula C8H5F3O and IUPAC name 1-(3,4,5-trifluorophenyl)ethanone . This compound is characterized by its trifluorinated phenyl ring, which enhances its reactivity and utility in organic synthesis. It is commonly employed as a key intermediate in pharmaceuticals, agrochemicals, and advanced material science due to its electron-withdrawing properties and stability under various reaction conditions. Available in >98% purity, this product is rigorously tested via GC, NMR, and HPLC to ensure consistency and reliability for research applications. Suitable for use in Suzuki couplings, Grignard reactions, and other cross-coupling methodologies.

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Description

Description

3′,4′,5′-Trifluoroacetophenone (CAS No. 220141-73-1) is a high-purity fluorinated aromatic ketone with the molecular formula C8H5F3O and IUPAC name 1-(3,4,5-trifluorophenyl)ethanone. This compound is characterized by its trifluorinated phenyl ring, which enhances its reactivity and utility in organic synthesis. It is commonly employed as a key intermediate in pharmaceuticals, agrochemicals, and advanced material science due to its electron-withdrawing properties and stability under various reaction conditions. Available in >98% purity, this product is rigorously tested via GC, NMR, and HPLC to ensure consistency and reliability for research applications. Suitable for use in Suzuki couplings, Grignard reactions, and other cross-coupling methodologies.

  • CAS No: 220141-73-1
  • Molecular Formula: C8H5F3O
  • Molecular Weight: 174.12
  • Exact Mass: 174.02924926
  • Monoisotopic Mass: 174.02924926
  • IUPAC Name: 1-(3,4,5-trifluorophenyl)ethanone
  • SMILES: CC(=O)C1=CC(=C(C(=C1)F)F)F
  • Synonyms: 3′,4′,5′-Trifluoroacetophenone, 220141-73-1, DTXSID40380292, DTXCID70331318, 671-898-5

Application

3′,4′,5′-Trifluoroacetophenone is widely used as a building block in the synthesis of fluorinated pharmaceutical compounds, particularly in the development of kinase inhibitors and antimicrobial agents. Its trifluoromethyl group enhances metabolic stability and bioavailability in drug candidates. Additionally, it serves as a precursor in agrochemical research for designing novel herbicides and pesticides. Researchers also utilize this compound in material science to develop liquid crystals and specialty polymers with unique electronic properties.

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