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Atomfair (2s,3s)-1-Tert-butyl 2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate C11H19NO5

Description (2S,3S)-1-Tert-butyl 2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate (CAS: 2165775-01-7) is a high-purity chiral building block widely used in pharmaceutical synthesis and asymmetric catalysis. This compound, with the molecular formula C11H19NO5, features a stereochemically defined pyrrolidine core with hydroxyl and dual carboxylate ester functionalities, making it a versatile intermediate for complex organic transformations. Its IUPAC name is 1-O-tert-butyl 2-O-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate , and it is supplied as a white to off-white crystalline solid with ??95% purity (HPLC). The tert-butyl and methyl ester groups enhance solubility in organic solvents while enabling selective deprotection strategies. Strict quality control ensures batch-to-batch consistency for research and scale-up applications. Store…

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Description

Description

(2S,3S)-1-Tert-butyl 2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate (CAS: 2165775-01-7) is a high-purity chiral building block widely used in pharmaceutical synthesis and asymmetric catalysis. This compound, with the molecular formula C11H19NO5, features a stereochemically defined pyrrolidine core with hydroxyl and dual carboxylate ester functionalities, making it a versatile intermediate for complex organic transformations. Its IUPAC name is 1-O-tert-butyl 2-O-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate, and it is supplied as a white to off-white crystalline solid with ??95% purity (HPLC). The tert-butyl and methyl ester groups enhance solubility in organic solvents while enabling selective deprotection strategies. Strict quality control ensures batch-to-batch consistency for research and scale-up applications. Store under inert atmosphere at 2-8??C to maintain stability.

  • CAS No: 2165775-01-7
  • Molecular Formula: C11H19NO5
  • Molecular Weight: 245.27
  • Exact Mass: 245.12632271
  • Monoisotopic Mass: 245.12632271
  • IUPAC Name: 1-O-tert-butyl 2-O-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate
  • SMILES: CC(C)(C)OC(=O)N1CCC(C1C(=O)OC)O
  • Synonyms: (2s,3s)-1-tert-butyl 2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate, 108998-76-1, 1-(tert-Butyl) 2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate, MFCD13248611, MFCD19440825

Application

This compound serves as a key chiral synthon in the asymmetric synthesis of bioactive molecules, particularly for pyrrolidine-containing pharmaceuticals. It is employed in medicinal chemistry for constructing stereocenters in protease inhibitors and receptor modulators. The hydroxyl group facilitates further functionalization via oxidation or nucleophilic substitution, while the ester groups allow controlled hydrolysis or cross-coupling reactions.

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