Description

Description

5-Methoxyspiro[2.3]hexan-1-amine hydrochloride (CAS No. 2137780-65-3) is a high-purity organic compound with the molecular formula C₇H₁₄ClNO. This spirocyclic amine derivative features a unique structural motif, combining a methoxy-substituted spiro[2.3]hexane ring with an amine hydrochloride functional group. The compound is supplied as a white to off-white crystalline powder with ??95% purity (HPLC). It is soluble in polar organic solvents such as methanol, ethanol, and DMSO, but has limited solubility in water. This building block is particularly valuable for medicinal chemistry research and pharmaceutical development due to its constrained spirocyclic architecture, which can impart improved metabolic stability and target selectivity in drug candidates. The hydrochloride salt form ensures enhanced stability and handling characteristics. Store at 2-8??C in a tightly sealed container under inert atmosphere for optimal shelf life.

Application

5-Methoxyspiro[2.3]hexan-1-amine hydrochloride serves as a versatile scaffold in drug discovery, particularly for central nervous system (CNS) targets due to its ability to cross the blood-brain barrier. The spirocyclic structure makes it valuable for developing novel GPCR modulators and enzyme inhibitors with improved pharmacological profiles. Researchers utilize this compound as a key intermediate in the synthesis of potential therapeutics for neurological disorders and psychiatric conditions. Its constrained geometry also facilitates exploration of three-dimensional chemical space in fragment-based drug design.

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