Description

Description

2-Fluoro-4-(trifluoromethyl)benzyl bromide (CAS No. 206860-48-2) is a high-purity halogenated aromatic compound with the molecular formula C₈H₅BrF₄. This organobromine reagent is a versatile building block for synthetic organic chemistry, particularly in the preparation of pharmaceuticals, agrochemicals, and specialty materials. The presence of both fluorine and bromine substituents on the benzyl ring enhances its reactivity in nucleophilic substitutions, cross-coupling reactions, and as a precursor for Grignard reagents. Its IUPAC name is 1-(bromomethyl)-2-fluoro-4-(trifluoromethyl)benzene, and it is characterized by its clear to pale yellow liquid form under standard conditions. Suitable for use in inert atmospheres due to sensitivity to moisture and air, this compound is packaged in amber glass vials to ensure stability. Ideal for researchers in medicinal chemistry and material science seeking to incorporate trifluoromethyl and fluoro motifs into target molecules.

Application

2-Fluoro-4-(trifluoromethyl)benzyl bromide is widely used as a key intermediate in the synthesis of biologically active compounds, particularly in the development of fluorinated pharmaceuticals and agrochemicals. Its reactive benzyl bromide moiety facilitates efficient functionalization via nucleophilic displacement or metal-catalyzed cross-coupling reactions. Researchers employ this compound to introduce trifluoromethylphenyl groups into molecules, enhancing metabolic stability and lipophilicity in drug candidates. It is also utilized in material science for modifying polymers and liquid crystals to tailor their electronic or optical properties.

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