Description

Description

4-Bromo-3,5-difluoroanisole (CAS No. 202865-61-0) is a high-purity halogenated aromatic compound with the molecular formula C₇H₅BrF₂O. This specialty chemical, also known by its IUPAC name 2-bromo-1,3-difluoro-5-methoxybenzene, features a benzene ring substituted with bromo, fluoro, and methoxy functional groups at the 2, 1/3, and 5 positions respectively. Its unique structure makes it a valuable intermediate in pharmaceutical synthesis, agrochemical production, and advanced material research. The compound is supplied as a clear to pale yellow liquid (or low-melting solid) with ??95% purity (GC), packaged under inert gas to ensure stability. Suitable for use in Suzuki couplings, nucleophilic substitutions, and other organometallic reactions. Store at 2-8??C in a tightly sealed container away from light and moisture.

Key Attributes:

• CAS: 202865-61-0
• Molecular Weight: 223.02 g/mol
• Boiling Point: ~210-215??C (estimated)
• Density: ~1.6 g/cm³ (predicted)
• Hazard Codes: Xi (Irritant)

Application

4-Bromo-3,5-difluoroanisole serves as a versatile building block in medicinal chemistry, particularly for introducing difluoromethoxy-substituted aromatic systems into drug candidates. It is employed in the synthesis of kinase inhibitors and CNS-active compounds where fluorine substitution modulates bioavailability. In materials science, this compound acts as a precursor for liquid crystals and OLED intermediates. The bromine moiety facilitates cross-coupling reactions for constructing complex heterocycles.

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