Description

Description

4-Fluoro-2-(trifluoromethyl)aniline (CAS No. 175278-17-8) is a high-purity fluorinated aromatic amine with the molecular formula C₇H₅F₄N. This compound is characterized by its unique trifluoromethyl and fluoro substituents on the aniline ring, making it a valuable intermediate in organic synthesis and pharmaceutical research. Its IUPAC name is 4-fluoro-2-(trifluoromethyl)aniline, and it is also known by synonyms such as 2-Amino-5-fluorobenzotrifluoride and alpha,alpha,alpha,4-Tetrafluoro-o-toluidine. This reagent is supplied as a clear to pale yellow liquid with high chemical stability, suitable for use in nucleophilic substitution reactions, cross-coupling reactions, and as a building block for agrochemicals and active pharmaceutical ingredients (APIs). Ideal for researchers requiring precise fluorination in their synthetic pathways.

Application

4-Fluoro-2-(trifluoromethyl)aniline is widely used as a key intermediate in the synthesis of fluorinated pharmaceuticals, agrochemicals, and specialty materials. Its electron-withdrawing trifluoromethyl group enhances reactivity in palladium-catalyzed cross-coupling reactions, making it valuable for constructing complex aromatic systems. This compound is also employed in the development of liquid crystals and advanced polymers due to its thermal and chemical stability. Researchers utilize it to introduce fluorine motifs into target molecules, improving bioavailability and metabolic resistance in drug candidates.

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