Description

Description

4-Cyano-2-fluorobenzoic acid (CAS No. 164149-28-4) is a high-purity fluorinated benzoic acid derivative with the molecular formula C₈H₄FNO₂. This compound features a cyano group at the para position and a fluorine substituent at the ortho position relative to the carboxylic acid functionality, making it a versatile intermediate for pharmaceutical, agrochemical, and materials science research. Its IUPAC name is 4-cyano-2-fluorobenzoic acid, and it is supplied as a white to off-white crystalline powder with ??95% purity (HPLC). Ideal for coupling reactions, metal-catalyzed transformations, and as a building block for heterocyclic synthesis, this product is rigorously tested for consistency and stored under controlled conditions to ensure stability. Available in scalable quantities from milligrams to kilograms, it is packaged in amber glass vials or sealed polyethylene containers to prevent degradation.

Application

4-Cyano-2-fluorobenzoic acid is widely used as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS and metabolic disorders. Its electron-withdrawing cyano and fluorine groups enhance reactivity in nucleophilic aromatic substitution (S_NAr) reactions, making it valuable for constructing complex heterocycles. Researchers also employ it in the development of liquid crystal materials and agrochemicals due to its ability to modulate electronic and steric properties. The compound’s carboxylic acid moiety allows for further derivatization via esterification or amide coupling.

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