Description

Description

5-Methylpicolinonitrile (CAS No. 1620-77-5) is a high-purity organic compound with the molecular formula C₇H₆N₂ and the IUPAC name 5-methylpyridine-2-carbonitrile. This specialized nitrile derivative is a valuable building block in pharmaceutical and agrochemical synthesis, offering a reactive cyano group adjacent to a methyl-substituted pyridine ring. Our product is rigorously tested to ensure ??98% purity (HPLC) and is supplied as a white to off-white crystalline powder with excellent batch-to-batch consistency. Suitable for use in cross-coupling reactions, heterocyclic synthesis, and as a precursor for bioactive molecules. Packaged under inert gas in amber glass vials with PTFE-lined caps to ensure stability. Technical data sheet includes ¹H/¹³C NMR spectra, GC-MS analysis, and residual solvent reports. Store in a cool, dry place at 2-8??C under inert atmosphere.

Application

5-Methylpicolinonitrile serves as a key intermediate in the synthesis of novel pyridine-containing pharmaceuticals, particularly in the development of kinase inhibitors and CNS-active compounds. The compound’s reactive nitrile group enables facile conversion to amidines, tetrazoles, and other nitrogen-rich heterocycles important in medicinal chemistry. Researchers utilize this building block in palladium-catalyzed cross-coupling reactions to construct complex bioactive molecules. In material science, it finds application as a precursor for liquid crystal intermediates and coordination complexes with transition metals.

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