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Atomfair 4′-Bromo-2,2,2-trifluoroacetophenone C8H4BrF3O

Description 4′-Bromo-2,2,2-trifluoroacetophenone (CAS No. 16184-89-7) is a high-purity brominated trifluoroacetophenone derivative with the molecular formula C8H4BrF3O. This compound, also known by its IUPAC name 1-(4-bromophenyl)-2,2,2-trifluoroethanone , is a versatile building block in organic synthesis and pharmaceutical research. Its unique structure, featuring a bromine substituent at the para position and a trifluoromethyl ketone moiety, makes it valuable for nucleophilic aromatic substitution reactions, cross-coupling reactions, and as a precursor for fluorinated intermediates. The compound is supplied as a crystalline solid with ??98% purity (GC), ensuring consistency for sensitive applications. Proper storage under inert conditions is recommended to maintain stability.

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Description

Description

4′-Bromo-2,2,2-trifluoroacetophenone (CAS No. 16184-89-7) is a high-purity brominated trifluoroacetophenone derivative with the molecular formula C8H4BrF3O. This compound, also known by its IUPAC name 1-(4-bromophenyl)-2,2,2-trifluoroethanone, is a versatile building block in organic synthesis and pharmaceutical research. Its unique structure, featuring a bromine substituent at the para position and a trifluoromethyl ketone moiety, makes it valuable for nucleophilic aromatic substitution reactions, cross-coupling reactions, and as a precursor for fluorinated intermediates. The compound is supplied as a crystalline solid with ??98% purity (GC), ensuring consistency for sensitive applications. Proper storage under inert conditions is recommended to maintain stability.

  • CAS No: 16184-89-7
  • Molecular Formula: C8H4BrF3O
  • Molecular Weight: 253.02
  • Exact Mass: 251.93976
  • Monoisotopic Mass: 251.93976
  • IUPAC Name: 1-(4-bromophenyl)-2,2,2-trifluoroethanone
  • SMILES: C1=CC(=CC=C1C(=O)C(F)(F)F)Br
  • Synonyms: 4′-Bromo-2,2,2-trifluoroacetophenone, 16184-89-7, DTXSID00345342, DTXCID50296416, 629-304-7

Application

4′-Bromo-2,2,2-trifluoroacetophenone is widely used as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty materials. Its reactivity enables the preparation of trifluoromethylated compounds with enhanced biological activity or metabolic stability. Researchers employ this compound in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions to construct complex fluorinated aromatics. It also serves as a precursor for ligands and catalysts in asymmetric synthesis.

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