Description

Description

1-(Bromomethyl)-2,3-difluoro-benzene (CAS No. 159277-47-1) is a high-purity aromatic organobromine compound with the molecular formula C₇H₅BrF₂. This specialized chemical features a bromomethyl group at the 1-position and fluorine substituents at the 2- and 3-positions of the benzene ring, making it a valuable bifunctional building block for synthetic organic chemistry. Offered as a clear to pale yellow liquid (exact physical state to be verified), it is packaged under inert gas to ensure stability and shipped with comprehensive analytical data including GC/HPLC purity, NMR, and MSDS. Ideal for nucleophilic substitution reactions, metal-catalyzed cross-couplings, and as a precursor for pharmaceuticals or agrochemical intermediates. Strictly for research use in controlled laboratory settings.

Application

This compound serves as a versatile reagent for introducing 2,3-difluorobenzyl motifs in medicinal chemistry, particularly in the development of kinase inhibitors and CNS-active compounds. The bromomethyl group enables efficient functionalization through Suzuki couplings or nucleophilic displacements to create novel scaffolds. Researchers utilize it to synthesize fluorinated liquid crystals for advanced display technologies. In material science, it acts as a monomer for specialty polymers with enhanced thermal and chemical resistance.

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