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Atomfair N,N-bis(trimethylsilyl)formamide BTSFA C7H19NOSi2

Description N,N-bis(trimethylsilyl)formamide (CAS No. 15500-60-4) is a highly specialized organosilicon compound with the molecular formula C7H19NOSi2. This reagent is widely utilized in organic synthesis as a potent silylating agent , particularly for the protection of sensitive functional groups such as amides, amines, and hydroxyl groups. Its unique structure, featuring two trimethylsilyl (TMS) groups, enhances its reactivity and selectivity in nucleophilic substitution reactions. This product is supplied as a clear, colorless liquid with high purity (>98%), ensuring optimal performance in demanding laboratory and industrial applications. Proper handling under inert conditions (e.g., nitrogen or argon) is recommended due to its moisture sensitivity.

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Description

Description

N,N-bis(trimethylsilyl)formamide (CAS No. 15500-60-4) is a highly specialized organosilicon compound with the molecular formula C7H19NOSi2. This reagent is widely utilized in organic synthesis as a potent silylating agent, particularly for the protection of sensitive functional groups such as amides, amines, and hydroxyl groups. Its unique structure, featuring two trimethylsilyl (TMS) groups, enhances its reactivity and selectivity in nucleophilic substitution reactions. This product is supplied as a clear, colorless liquid with high purity (>98%), ensuring optimal performance in demanding laboratory and industrial applications. Proper handling under inert conditions (e.g., nitrogen or argon) is recommended due to its moisture sensitivity.

  • CAS No: 15500-60-4
  • Molecular Formula: C7H19NOSi2
  • Molecular Weight: 189.40
  • Exact Mass: 189.10051730
  • Monoisotopic Mass: 189.10051730
  • IUPAC Name: N,N-bis(trimethylsilyl)formamide
  • SMILES: C[Si](C)(C)N(C=O)[Si](C)(C)C
  • Synonyms: N,N-Bis(trimethylsilyl)formamide, Formamide, N,N-bis(trimethylsilyl)-, Bis(trimethylsilyl)formamide, EINECS 239-530-4, Formamide, 2TMS derivative

Application

N,N-bis(trimethylsilyl)formamide is extensively used in peptide synthesis as a silylating agent to protect reactive intermediates. It also serves as a key reagent in pharmaceutical manufacturing for the derivatization of polar compounds to improve their volatility in GC-MS analysis. Additionally, it finds applications in material science for surface modification of silica-based substrates.

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