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Atomfair Cycloguanil hydrochloride Cycloguanil HCl C11H15Cl2N5

Description Cycloguanil hydrochloride (CAS 15492-38-3) is a high-purity chemical compound with the molecular formula C11H15Cl2N5and IUPAC name 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine;hydrochloride . This white to off-white crystalline powder is a metabolite of the antimalarial drug proguanil, exhibiting potent dihydrofolate reductase (DHFR) inhibition. With a molecular weight of 288.18 g/mol, it is soluble in water and polar organic solvents. Ideal for pharmaceutical research, Cycloguanil hydrochloride is rigorously tested for purity (typically ??95% by HPLC) and stability, ensuring reliable performance in drug development and biochemical studies. Packaged under inert conditions to prevent degradation, this compound is a critical reference standard for antimalarial research and infectious…

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Description

Description

Cycloguanil hydrochloride (CAS 15492-38-3) is a high-purity chemical compound with the molecular formula C11H15Cl2N5 and IUPAC name 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine;hydrochloride. This white to off-white crystalline powder is a metabolite of the antimalarial drug proguanil, exhibiting potent dihydrofolate reductase (DHFR) inhibition. With a molecular weight of 288.18 g/mol, it is soluble in water and polar organic solvents. Ideal for pharmaceutical research, Cycloguanil hydrochloride is rigorously tested for purity (typically ??95% by HPLC) and stability, ensuring reliable performance in drug development and biochemical studies. Packaged under inert conditions to prevent degradation, this compound is a critical reference standard for antimalarial research and infectious disease studies.

  • CAS No: 15492-38-3
  • Molecular Formula: C11H15Cl2N5
  • Molecular Weight: 288.17
  • Exact Mass: 287.0704509
  • Monoisotopic Mass: 287.0704509
  • IUPAC Name: 1-(4-chlorophenyl)-6,6-dimethyl-1,3,5-triazine-2,4-diamine;hydrochloride
  • SMILES: CC1(N=C(N=C(N1C2=CC=C(C=C2)Cl)N)N)C.Cl
  • Synonyms: CYCLOGUANIL HYDROCHLORIDE, 152-53-4, Cycloguanil HCl, Chlorcycloguanil, Chloroguanide triazine hydrochloride

Application

Cycloguanil hydrochloride is primarily used in antimalarial research as a reference standard for studying DHFR inhibition mechanisms. It serves as a key metabolite in pharmacokinetic studies of proguanil, aiding in drug metabolism and efficacy evaluations. Researchers also employ it in in vitro assays to investigate resistance patterns in Plasmodium falciparum strains.

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