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Atomfair Voxilaprevir GS-9857, GS9857 C40H52F4N6O9S

Description Voxilaprevir (CAS: 1535212-07-7) is a high-purity small molecule inhibitor with the molecular formula C40H52F4N6O9S . It is a potent antiviral agent specifically designed for research applications targeting hepatitis C virus (HCV) NS3/4A protease. This compound features a complex pentacyclic structure with multiple stereocenters, ensuring high selectivity and efficacy. Voxilaprevir is supplied as a lyophilized powder or solution, rigorously tested for purity (>98% by HPLC) and stability under controlled conditions. Ideal for biochemical assays, virology studies, and drug discovery programs, it is packaged in amber vials with inert gas to maintain integrity. Store at -20??C and handle under anhydrous conditions.

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Description

Description

Voxilaprevir (CAS: 1535212-07-7) is a high-purity small molecule inhibitor with the molecular formula C40H52F4N6O9S. It is a potent antiviral agent specifically designed for research applications targeting hepatitis C virus (HCV) NS3/4A protease. This compound features a complex pentacyclic structure with multiple stereocenters, ensuring high selectivity and efficacy. Voxilaprevir is supplied as a lyophilized powder or solution, rigorously tested for purity (>98% by HPLC) and stability under controlled conditions. Ideal for biochemical assays, virology studies, and drug discovery programs, it is packaged in amber vials with inert gas to maintain integrity. Store at -20??C and handle under anhydrous conditions.

  • CAS No: 1535212-07-7
  • Molecular Formula: C40H52F4N6O9S
  • Molecular Weight: 868.9
  • Exact Mass: 868.34526108
  • Monoisotopic Mass: 868.34526108
  • IUPAC Name: (1R,18R,20R,24S,27S,28S)-24-tert-butyl-N-[(1R,2R)-2-(difluoromethyl)-1-[(1-methylcyclopropyl)sulfonylcarbamoyl]cyclopropyl]-28-ethyl-13,13-difluoro-7-methoxy-22,25-dioxo-2,21-dioxa-4,11,23,26-tetrazapentacyclo[24.2.1.03,12.05,10.018,20]nonacosa-3,5(10),6,8,11-pentaene-27-carboxamide
  • SMILES: CC[C@@H]1[C@@H]2CN([C@@H]1C(=O)N[C@@]3(C[C@H]3C(F)F)C(=O)NS(=O)(=O)C4(CC4)C)C(=O)[C@@H](NC(=O)O[C@@H]5C[C@H]5CCCCC(C6=NC7=C(C=C(C=C7)OC)N=C6O2)(F)F)C(C)(C)C
  • Synonyms: Voxilaprevir, 1535212-07-7, GS9857, Voxilaprevir [INN], GS-9857

Application

Voxilaprevir is a key component in hepatitis C research, specifically inhibiting the NS3/4A protease to disrupt viral replication. It is used in combination therapies (e.g., with sofosbuvir) for genotype 1-6 HCV studies. Researchers employ it in in vitro assays and preclinical models to evaluate antiviral potency and resistance profiles. Its mechanism of action makes it valuable for probing protease function and developing next-generation HCV therapeutics.

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