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Atomfair Difluoromethanesulphonyl chloride CHClF2O2S
Description Difluoromethanesulfonyl Chloride (CAS No. 1512-30-7) is a highly reactive organosulfur compound with the molecular formula CHClF2O2S . This colorless to pale yellow liquid is a versatile sulfonylating agent widely used in organic synthesis and pharmaceutical research. Its unique structure, featuring both fluorine and sulfonyl chloride functional groups, makes it a valuable intermediate for introducing difluoromethylsulfonyl moieties into target molecules. The compound is moisture-sensitive and should be stored under inert conditions to prevent hydrolysis. With a purity of ??98% (GC), our product is ideal for nucleophilic substitution reactions, cross-coupling chemistry, and as a precursor for sulfonamide derivatives. Suitable for use…
Description
Description
Difluoromethanesulfonyl Chloride (CAS No. 1512-30-7) is a highly reactive organosulfur compound with the molecular formula CHClF2O2S. This colorless to pale yellow liquid is a versatile sulfonylating agent widely used in organic synthesis and pharmaceutical research. Its unique structure, featuring both fluorine and sulfonyl chloride functional groups, makes it a valuable intermediate for introducing difluoromethylsulfonyl moieties into target molecules. The compound is moisture-sensitive and should be stored under inert conditions to prevent hydrolysis. With a purity of ??98% (GC), our product is ideal for nucleophilic substitution reactions, cross-coupling chemistry, and as a precursor for sulfonamide derivatives. Suitable for use in medicinal chemistry, agrochemical development, and materials science applications.
- CAS No: 1512-30-7
- Molecular Formula: CHClF2O2S
- Molecular Weight: 150.53
- Exact Mass: 149.9353845
- Monoisotopic Mass: 149.9353845
- IUPAC Name: difluoromethanesulfonyl chloride
- SMILES: C(F)(F)S(=O)(=O)Cl
- Synonyms: 1512-30-7, Difluoromethanesulphonyl chloride, EINECS 216-150-7, DTXSID00164732, 1,1-Difluoromethanesulfonyl chloride
Application
Difluoromethanesulfonyl chloride serves as a key building block in pharmaceutical synthesis, particularly for creating sulfonamide drugs with enhanced metabolic stability. It’s widely employed in nucleophilic substitution reactions to introduce the difluoromethanesulfonyl group into organic molecules. The compound finds special utility in the development of protease inhibitors and other biologically active molecules where the difluoromethyl group can improve lipophilicity and membrane permeability. Researchers also utilize it as a precursor for synthesizing sulfonyl fluorides used in chemical biology applications.
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