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Atomfair 2′-Deoxy-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-fluorouridine C30H29FN2O7

Description 2′-Deoxy-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-fluorouridine (CAS No. 144822-63-9) is a high-purity fluorinated nucleoside derivative with the molecular formula C30H29FN2O7. This compound features a dimethoxytrityl (DMT) protecting group at the 5′-position, enhancing its stability and making it a critical intermediate in oligonucleotide synthesis, particularly for modified RNA and DNA sequences. The 2′-fluoro modification confers increased nuclease resistance, making it valuable for therapeutic and diagnostic applications. Suitable for researchers in pharmaceutical development, molecular biology, and nucleic acid chemistry , this product is rigorously tested for purity (typically ??95% by HPLC) and supplied under controlled conditions to ensure optimal performance in sensitive reactions.

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Description

Description

2′-Deoxy-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-fluorouridine (CAS No. 144822-63-9) is a high-purity fluorinated nucleoside derivative with the molecular formula C30H29FN2O7. This compound features a dimethoxytrityl (DMT) protecting group at the 5′-position, enhancing its stability and making it a critical intermediate in oligonucleotide synthesis, particularly for modified RNA and DNA sequences. The 2′-fluoro modification confers increased nuclease resistance, making it valuable for therapeutic and diagnostic applications. Suitable for researchers in pharmaceutical development, molecular biology, and nucleic acid chemistry, this product is rigorously tested for purity (typically ??95% by HPLC) and supplied under controlled conditions to ensure optimal performance in sensitive reactions.

  • CAS No: 144822-63-9
  • Molecular Formula: C30H29FN2O7
  • Molecular Weight: 548.6
  • Exact Mass: 548.19587943
  • Monoisotopic Mass: 548.19587943
  • IUPAC Name: 1-[5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-3-fluoro-4-hydroxyoxolan-2-yl]pyrimidine-2,4-dione
  • SMILES: COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=C(C=C3)OC)OCC4C(C(C(O4)N5C=CC(=O)NC5=O)F)O
  • Synonyms: SCHEMBL19026961, PD196605, SY289911, 2′-Deoxy-5′-O-[bis(4-methoxyphenyl)phenylmethyl]-2′-fluorouridine, 5 inverted exclamation mark -O-(4,4 inverted exclamation mark -Dimethoxytrityl)-2 inverted exclamation mark -fluoro-2 inverted exclamation mark -deoxyuridine

Application

This fluorinated nucleoside derivative is primarily used in antisense oligonucleotide (ASO) synthesis and siRNA therapeutics due to its enhanced binding affinity and metabolic stability. It serves as a key building block in the production of modified nucleic acids for gene silencing, diagnostics, and targeted drug delivery. Researchers also employ it in structural studies to investigate RNA-protein interactions and enzyme mechanisms.

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