Description

Description

2,4-Difluorophenylboronic acid (CAS No. 144025-03-6) is a high-purity boronic acid derivative with the molecular formula C₆H₅BF₂O₂. This organoboron compound is widely utilized in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern synthetic organic chemistry. The presence of two fluorine atoms at the 2- and 4-positions of the phenyl ring enhances its reactivity and selectivity in palladium-catalyzed transformations. Our product is rigorously tested to ensure ??95% purity (HPLC) and is supplied as a white to off-white crystalline powder, packaged under inert conditions to maintain stability. Ideal for pharmaceutical intermediates, material science research, and ligand design, this reagent is a staple in high-throughput synthesis and medicinal chemistry applications.

Application

2,4-Difluorophenylboronic acid is a key building block in the synthesis of biaryl compounds via Suzuki-Miyaura cross-coupling, enabling the formation of carbon-carbon bonds under mild conditions. It is particularly valuable in the development of fluorinated pharmaceuticals and agrochemicals due to its enhanced metabolic stability and bioavailability. Researchers also employ this reagent in the design of boron-based sensors and MOF (Metal-Organic Framework) materials. Its orthogonal reactivity makes it suitable for sequential functionalization in complex molecule assembly.

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