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Atomfair 3-Trifluoromethylphenylboronic acid 3-CF3PhB(OH)2 C7H6BF3O2

Description 3-Trifluoromethylphenylboronic acid (CAS No. 1423-26-3) is a high-purity boronic acid derivative with the molecular formula C7H6BF3O2, widely used in organic synthesis and pharmaceutical research. This compound, also known by its IUPAC name [3-(trifluoromethyl)phenyl]boronic acid , features a phenyl ring substituted with a boronic acid group (?CB(OH)2) and a trifluoromethyl (?CCF3) group at the meta position, offering unique reactivity in Suzuki-Miyaura cross-coupling reactions. Its trifluoromethyl group enhances lipophilicity and metabolic stability, making it valuable in medicinal chemistry and drug development. Available in crystalline form, this reagent is rigorously tested for purity (typically ??95-98% by HPLC) and is suitable for use…

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Description

Description

3-Trifluoromethylphenylboronic acid (CAS No. 1423-26-3) is a high-purity boronic acid derivative with the molecular formula C7H6BF3O2, widely used in organic synthesis and pharmaceutical research. This compound, also known by its IUPAC name [3-(trifluoromethyl)phenyl]boronic acid, features a phenyl ring substituted with a boronic acid group (?CB(OH)2) and a trifluoromethyl (?CCF3) group at the meta position, offering unique reactivity in Suzuki-Miyaura cross-coupling reactions. Its trifluoromethyl group enhances lipophilicity and metabolic stability, making it valuable in medicinal chemistry and drug development. Available in crystalline form, this reagent is rigorously tested for purity (typically ??95-98% by HPLC) and is suitable for use in anhydrous or aqueous conditions. Store in a cool, dry place under inert atmosphere to maintain stability.

  • CAS No: 1423-26-3
  • Molecular Formula: C7H6BF3O2
  • Molecular Weight: 189.93
  • Exact Mass: 190.0412941
  • Monoisotopic Mass: 190.0412941
  • IUPAC Name: [3-(trifluoromethyl)phenyl]boronic acid
  • SMILES: B(C1=CC(=CC=C1)C(F)(F)F)(O)O
  • Synonyms: 3-Trifluoromethylphenylboronic acid, (3-(Trifluoromethyl)phenyl)boronic acid, [3-(trifluoromethyl)phenyl]boronic Acid, 604-284-2, 675-106-9

Application

3-Trifluoromethylphenylboronic acid is a versatile building block in organoboron chemistry, particularly for Suzuki-Miyaura cross-coupling reactions to synthesize biaryl compounds. It is employed in pharmaceutical research to introduce trifluoromethylphenyl motifs, which improve drug bioavailability and binding affinity. The compound also serves as a precursor in materials science for designing fluorinated polymers and liquid crystals. Its stability under mild conditions makes it ideal for iterative coupling strategies in complex molecule synthesis.

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