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Atomfair 3,5-Bis(trifluoromethyl)benzenethiol C8H4F6S

Description 3,5-Bis(trifluoromethyl)benzenethiol (CAS No. 130783-02-7) is a high-purity organosulfur compound with the molecular formula C8H4F6S . This specialized reagent features a benzene ring substituted with two trifluoromethyl (?CCF3) groups at the 3 and 5 positions and a thiol (?CSH) functional group, making it a valuable building block for advanced organic synthesis. Its unique structure imparts exceptional electron-withdrawing properties and reactivity, particularly in nucleophilic aromatic substitution and metal-catalyzed coupling reactions. Offered as a clear to pale yellow liquid with ??95% purity (GC), it is rigorously tested for consistency and stored under inert conditions to ensure stability. Ideal for pharmaceutical intermediates, ligand…

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Description

Description

3,5-Bis(trifluoromethyl)benzenethiol (CAS No. 130783-02-7) is a high-purity organosulfur compound with the molecular formula C8H4F6S. This specialized reagent features a benzene ring substituted with two trifluoromethyl (?CCF3) groups at the 3 and 5 positions and a thiol (?CSH) functional group, making it a valuable building block for advanced organic synthesis. Its unique structure imparts exceptional electron-withdrawing properties and reactivity, particularly in nucleophilic aromatic substitution and metal-catalyzed coupling reactions. Offered as a clear to pale yellow liquid with ??95% purity (GC), it is rigorously tested for consistency and stored under inert conditions to ensure stability. Ideal for pharmaceutical intermediates, ligand design, and materials science applications requiring fluorinated aromatic thiols.

  • CAS No: 130783-02-7
  • Molecular Formula: C8H4F6S
  • Molecular Weight: 246.17
  • Exact Mass: 245.99379027
  • Monoisotopic Mass: 245.99379027
  • IUPAC Name: 3,5-bis(trifluoromethyl)benzenethiol
  • SMILES: C1=C(C=C(C=C1C(F)(F)F)S)C(F)(F)F
  • Synonyms: 3,5-Bis(trifluoromethyl)benzenethiol, 130783-02-7, DTXSID20333802, DTXCID90284892, 626-137-1

Application

3,5-Bis(trifluoromethyl)benzenethiol serves as a critical precursor in the synthesis of fluorinated ligands for transition metal catalysis, enhancing electron deficiency in catalytic systems. It is employed in pharmaceutical research to develop bioactive molecules with improved metabolic stability via CF3 incorporation. The compound also finds use in materials science for modifying surface properties of polymers and creating sulfur-containing fluorinated architectures.

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