Atomfair tert-Butyl 3,3-difluoro-5-oxopiperidine-1-carboxylate C10H15F2NO3

Description tert-Butyl 3,3-difluoro-5-oxopiperidine-1-carboxylate (CAS No. 1303974-84-6) is a high-purity fluorinated piperidine derivative with the molecular formula C10H15F2NO3. This compound features a tert-butyl carbamate-protected nitrogen and a ketone functionality at the 5-position, making it a versatile intermediate for organic synthesis and medicinal chemistry applications. Its unique 3,3-difluoro substitution enhances reactivity and selectivity in nucleophilic and electrophilic reactions. Ideal for researchers developing novel pharmaceuticals, agrochemicals, or specialty materials, this compound is supplied with comprehensive analytical data (including1H NMR,13C NMR, and LC-MS) to ensure quality and reproducibility. Store under inert conditions at -20??C for prolonged stability.

Description

tert-Butyl 3,3-difluoro-5-oxopiperidine-1-carboxylate (CAS No. 1303974-84-6) is a high-purity fluorinated piperidine derivative with the molecular formula C₁₀H₁₅F₂NO₃. This compound features a tert-butyl carbamate-protected nitrogen and a ketone functionality at the 5-position, making it a versatile intermediate for organic synthesis and medicinal chemistry applications. Its unique 3,3-difluoro substitution enhances reactivity and selectivity in nucleophilic and electrophilic reactions. Ideal for researchers developing novel pharmaceuticals, agrochemicals, or specialty materials, this compound is supplied with comprehensive analytical data (including ¹H NMR, ¹³C NMR, and LC-MS) to ensure quality and reproducibility. Store under inert conditions at -20??C for prolonged stability.

CAS No: 1303974-84-6
Molecular Formula: C10H15F2NO3
Molecular Weight: 235.23
Exact Mass: 235.10199966
Monoisotopic Mass: 235.10199966
IUPAC Name: tert-butyl 3,3-difluoro-5-oxopiperidine-1-carboxylate
SMILES: CC(C)(C)OC(=O)N1CC(=O)CC(C1)(F)F
Synonyms: tert-Butyl 3,3-difluoro-5-oxopiperidine-1-carboxylate, 1303974-84-6, tert-Butyl3,3-difluoro-5-oxopiperidine-1-carboxylate, AKOS040767134, BS-45913

Application

tert-Butyl 3,3-difluoro-5-oxopiperidine-1-carboxylate is a key building block in the synthesis of fluorinated bioactive molecules, particularly in drug discovery for protease inhibitors and CNS-targeting compounds. Its difluorinated scaffold improves metabolic stability and membrane permeability in candidate molecules. The ketone moiety allows further derivatization via reductive amination or Grignard reactions. Commonly used in parallel medicinal chemistry and library synthesis for lead optimization.

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