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Atomfair 1-(Propan-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole C12H21BN2O2

Description 1-(Propan-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS No. 1282518-60-8) is a high-purity boronate ester compound with the molecular formula C12H21BN2O2. This organoboron reagent features a pyrazole core functionalized with an isopropyl group and a pinacol boronate ester moiety, making it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions and other transition-metal-catalyzed transformations. The compound is supplied as a stable, crystalline solid with ??95% purity (HPLC) and is rigorously tested for moisture sensitivity. Ideal for pharmaceutical research, materials science, and agrochemical development, this reagent is packaged under inert gas to ensure maximum shelf life and reactivity. Each batch is accompanied by comprehensive analytical data including 1H…

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Description

Description

1-(Propan-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS No. 1282518-60-8) is a high-purity boronate ester compound with the molecular formula C12H21BN2O2. This organoboron reagent features a pyrazole core functionalized with an isopropyl group and a pinacol boronate ester moiety, making it a versatile intermediate for Suzuki-Miyaura cross-coupling reactions and other transition-metal-catalyzed transformations. The compound is supplied as a stable, crystalline solid with ??95% purity (HPLC) and is rigorously tested for moisture sensitivity. Ideal for pharmaceutical research, materials science, and agrochemical development, this reagent is packaged under inert gas to ensure maximum shelf life and reactivity. Each batch is accompanied by comprehensive analytical data including 1H NMR, 13C NMR, HPLC, and mass spectrometry for quality verification.

  • CAS No: 1282518-60-8
  • Molecular Formula: C12H21BN2O2
  • Molecular Weight: 236.12
  • Exact Mass: 236.1696081
  • Monoisotopic Mass: 236.1696081
  • IUPAC Name: 1-propan-2-yl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole
  • SMILES: B1(OC(C(O1)(C)C)(C)C)C2=CC=NN2C(C)C
  • Synonyms: 1282518-60-8, DTXSID30718343, 1-(Propan-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole, DTXCID90669089, 858-877-8

Application

This boronate ester is primarily used as a key building block in medicinal chemistry for the synthesis of biologically active pyrazole derivatives. It serves as a crucial intermediate in palladium-catalyzed cross-coupling reactions to create complex heterocyclic systems for drug discovery. The compound’s stability and reactivity make it particularly valuable for constructing protease inhibitors and kinase-targeted therapeutics. Researchers also utilize it in materials science for developing organic electronic materials and metal-organic frameworks (MOFs).

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