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Atomfair 4-Bromo-2-(difluoromethoxy)benzonitrile C8H4BrF2NO

Description 4-Bromo-2-(difluoromethoxy)benzonitrile (CAS No. 1261494-95-4) is a high-purity halogenated aromatic compound with the molecular formula C8H4BrF2NO. This specialty chemical features a benzonitrile core functionalized with a bromo substituent at the 4-position and a difluoromethoxy group at the 2-position, making it a valuable intermediate for pharmaceutical and agrochemical synthesis. The compound is supplied as a white to off-white crystalline powder with ??95% purity (HPLC), packaged under inert gas to ensure stability. Its unique structural motifs are particularly useful for Suzuki couplings, nucleophilic substitutions, and other palladium-catalyzed reactions. Store in a cool, dry place at 2-8??C with desiccant protection. Available in research…

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Description

Description

4-Bromo-2-(difluoromethoxy)benzonitrile (CAS No. 1261494-95-4) is a high-purity halogenated aromatic compound with the molecular formula C8H4BrF2NO. This specialty chemical features a benzonitrile core functionalized with a bromo substituent at the 4-position and a difluoromethoxy group at the 2-position, making it a valuable intermediate for pharmaceutical and agrochemical synthesis. The compound is supplied as a white to off-white crystalline powder with ??95% purity (HPLC), packaged under inert gas to ensure stability. Its unique structural motifs are particularly useful for Suzuki couplings, nucleophilic substitutions, and other palladium-catalyzed reactions. Store in a cool, dry place at 2-8??C with desiccant protection. Available in research quantities (100mg-10g) with optional certificates of analysis.

  • CAS No: 1261494-95-4
  • Molecular Formula: C8H4BrF2NO
  • Molecular Weight: 248.02
  • Exact Mass: 246.94443
  • Monoisotopic Mass: 246.94443
  • IUPAC Name: 4-bromo-2-(difluoromethoxy)benzonitrile
  • SMILES: C1=CC(=C(C=C1Br)OC(F)F)C#N
  • Synonyms: 4-bromo-2-(difluoromethoxy)benzonitrile, 1261494-95-4, 843-074-7, SCHEMBL14225100, TQU0291

Application

4-Bromo-2-(difluoromethoxy)benzonitrile serves as a key building block in medicinal chemistry for developing kinase inhibitors and GPCR modulators. The difluoromethoxy group enhances metabolic stability in drug candidates, while the bromo substituent enables cross-coupling reactions for structure-activity relationship studies. Researchers utilize this compound in fragment-based drug discovery, particularly for CNS-targeted therapeutics where fluorine incorporation improves blood-brain barrier penetration.

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