Description

Description

2-Fluoro-5-(trifluoromethyl)pyrimidine (CAS No. 1214344-68-9) is a high-purity fluorinated pyrimidine derivative with the molecular formula C₅H₂F₄N₂. This compound is a versatile building block in pharmaceutical and agrochemical research, offering unique reactivity due to the presence of both fluorine and trifluoromethyl groups on the pyrimidine ring. Its IUPAC name is 2-fluoro-5-(trifluoromethyl)pyrimidine, and it is supplied as a clear to pale-yellow liquid with ??95% purity (GC). Suitable for nucleophilic substitution reactions, cross-coupling, and other synthetic transformations, this reagent is ideal for medicinal chemistry, material science, and specialty chemical synthesis. Packaged under inert gas to ensure stability, it is available in quantities from 1g to 1kg with custom bulk options.

Application

2-Fluoro-5-(trifluoromethyl)pyrimidine is widely used as a key intermediate in the synthesis of bioactive molecules, particularly in the development of pharmaceuticals and agrochemicals. Its electron-deficient pyrimidine core and fluorine substituents make it valuable for designing kinase inhibitors and antiviral agents. Researchers also employ it in the preparation of fluorinated liquid crystals and advanced materials. The trifluoromethyl group enhances lipophilicity, improving drug-like properties in candidate compounds.

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