Description

Description

1-(3-Bromopyridin-2-yl)-2,2,2-trifluoroethan-1-amine (CAS No. 1213066-11-5) is a high-purity brominated pyridine derivative with the molecular formula C₇H₆BrF₃N₂. This specialized organic compound features a trifluoroethylamine moiety attached to a 3-bromopyridine scaffold, making it a valuable intermediate for pharmaceutical and agrochemical synthesis. With a molecular weight of 255.04 g/mol, this compound is characterized by its unique reactivity due to the electron-withdrawing effects of both the bromo and trifluoromethyl groups. Our product is rigorously tested to ensure ??95% purity (HPLC) and is supplied as a white to off-white crystalline solid under inert packaging to maintain stability. Ideal for cross-coupling reactions, nucleophilic substitutions, and as a building block for heterocyclic chemistry, this compound is a must-have for researchers developing novel bioactive molecules.

Application

1-(3-Bromopyridin-2-yl)-2,2,2-trifluoroethan-1-amine serves as a key intermediate in the synthesis of pharmaceuticals, particularly for the development of kinase inhibitors and CNS-targeting drugs. Its reactive bromopyridine group enables efficient Suzuki-Miyaura and Buchwald-Hartwig couplings, while the trifluoroethylamine moiety enhances metabolic stability in drug candidates. This compound is also utilized in agrochemical research for designing novel pesticides and herbicides with improved efficacy. Researchers leverage its structural features to modulate lipophilicity and electronic properties in medicinal chemistry optimization.

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