Description

Description

(8-Bromoquinolin-4-yl)methanol (CAS No. 1190315-99-1) is a high-purity brominated quinoline derivative with the molecular formula C₁₀H₈BrNO. This compound is a versatile intermediate in organic synthesis and pharmaceutical research, featuring a reactive bromine substituent at the 8-position and a hydroxymethyl group at the 4-position of the quinoline scaffold. Its well-defined structure (IUPAC name: (8-bromoquinolin-4-yl)methanol) makes it valuable for metal-catalyzed cross-coupling reactions, nucleophilic substitutions, and as a precursor for fluorescent probes or bioactive molecules. Supplied as an off-white to light yellow crystalline powder with ??95% purity (HPLC), it is packaged under inert gas to ensure stability. Suitable for research use only (RUO) in medicinal chemistry, materials science, and coordination chemistry applications.

Application

(8-Bromoquinolin-4-yl)methanol serves as a key building block in the synthesis of quinoline-based pharmaceuticals and agrochemicals. Researchers utilize its bromine moiety for Suzuki-Miyaura or Buchwald-Hartwig couplings to create complex heterocyclic systems. The hydroxymethyl group enables further derivatization into esters, ethers, or carbamates for drug discovery programs. It is also investigated as a potential ligand for transition metal catalysts in asymmetric synthesis.

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